Cellular mechanisms of multiple myeloma bone disease.
Cellular mechanisms of multiple myeloma bone disease.
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DOI：
10.1155/2013/289458
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发表时间：
2013
影响因子：
--
通讯作者：
Grano M
中科院分区：
文献类型：
--
作者：
Oranger A;Carbone C;Izzo M;Grano M
多发性骨髓瘤（MM）是一种恶性血液病的分化浆细胞的积累和增殖的骨髓。多发性骨髓瘤患者经常发生导致严重骨痛、溶骨性病变和病理性骨折的骨病。这些骨骼并发症不仅对生活质量有负面影响，而且可能影响总生存率。MM溶骨性骨病变是由于破骨细胞活化增加和成骨细胞分化减少引起的骨重建改变而引起的。在MM患者的骨髓微环境中，有充分的证据表明，许多细胞因子的产生失调，可能导致骨细胞活性的解偶联。这些分子不仅由直接导致MM骨病的恶性浆细胞产生，还由骨微环境中相互作用的骨、免疫和基质细胞产生。本文综述了MM骨疾病生物学的现有知识，特别是骨和免疫细胞在产生恶性浆细胞增殖和骨质溶解发展的关键细胞因子中的作用。因此，对MM发病机制的理解可能有助于发现能够恢复骨重建和降低肿瘤负荷的新型药物。
Multiple myeloma (MM) is a hematologic malignancy of differentiated plasma cells that accumulates and proliferates in the bone marrow. MM patients often develop bone disease that results in severe bone pain, osteolytic lesions, and pathologic fractures. These skeletal complications have not only a negative impact on quality of life but also a possible effect in overall survival. MM osteolytic bone lesions arise from the altered bone remodeling due to both increased osteoclast activation and decreased osteoblast differentiation. A dysregulated production of numerous cytokines that can contribute to the uncoupling of bone cell activity is well documented in the bone marrow microenvironment of MM patients. These molecules are produced not only by malignant plasma cells, that directly contribute to MM bone disease, but also by bone, immune, and stromal cells interacting with each other in the bone microenvironment. This review focuses on the current knowledge of MM bone disease biology, with particular regard on the role of bone and immune cells in producing cytokines critical for malignant plasma cell proliferation as well as in osteolysis development. Therefore, the understanding of MM pathogenesis could be useful to the discovery of novel agents that will be able to both restore bone remodelling and reduce tumor burden.
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影响因子：
45.3
作者：
Bjorkstrand, Bo;Iacobelli, Simona;Gahrton, Gosta
通讯作者：
Gahrton, Gosta
影响因子：
20.3
作者：
Abe, M;Hiura, K;Matsumoto, T
通讯作者：
Matsumoto, T
DOI：
10.1111/j.1749-6632.2011.06196.x
发表时间：
2011-01-01
期刊：
SKELETAL BIOLOGY AND MEDICINE I
影响因子：
--
作者：
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通讯作者：
Colucci, Silvia
影响因子：
20.3
作者：
Dankbar, B;Padró, T;Kienast, J
通讯作者：
Kienast, J
影响因子：
6.2
作者：
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通讯作者：
Croucher, Peter