Regional homogeneity abnormalities in patients with interictal migraine without aura: a resting-state study
Regional homogeneity abnormalities in patients with interictal migraine without aura: a resting-state study
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无先兆发作间期偏头痛患者的区域同质性异常：静息态研究
DOI：
10.1002/nbm.1796
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发表时间：
2012-05-01
影响因子：
2.9
通讯作者：
Tian, Jie
中科院分区：
文献类型：
--
作者：
Yu, Dahua;Yuan, Kai;Tian, Jie
先前的研究已经提供了无先兆偏头痛患者大脑结构和任务相关功能变化的证据。偏头痛患者静息状态下的大脑活动为该疾病的病理生理学提供了线索。然而，很少有研究集中在无先兆偏头痛患者的静息状态异常。在目前的研究中，我们采用了一种数据驱动的方法，区域同质性（ReHo），来分析无先兆偏头痛患者在静息状态下自发脑活动的局部特征。26名无先兆偏头痛患者和26名年龄、教育和性别匹配的健康志愿者参加了这项研究。与健康对照组相比，无先兆偏头痛患者的右喙前扣带回皮质（rACC），前额叶皮质（PFC），眶额皮质（OFC）和辅助运动区（SMA）的ReHo值显着降低。此外，我们发现，ReHo值与疾病的持续时间呈负相关，在右前扣带回和PFC。我们的研究结果表明，这些地区的休息状态异常可能与功能障碍的疼痛处理在无先兆偏头痛患者。我们希望我们的研究结果将提高对偏头痛的理解。版权所有（C）2011约翰威利父子有限公司
Previous studies have provided evidence of structural and task-related functional changes in the brains of patients with migraine without aura. Resting-state brain activity in patients with migraine provides clues to the pathophysiology of the disease. However, few studies have focused on the resting-state abnormalities in patients with migraine without aura. In the current study, we employed a data-driven method, regional homogeneity (ReHo), to analyze the local features of spontaneous brain activity in patients with migraine without aura during the resting state. Twenty-six patients with migraine without aura and 26 age-, education- and gender-matched healthy volunteers participated in this study. Compared with healthy controls, patients with migraine without aura showed a significant decrease in ReHo values in the right rostral anterior cingulate cortex (rACC), the prefrontal cortex (PFC), the orbitofrontal cortex (OFC) and the supplementary motor area (SMA). In addition, we found that ReHo values were negatively correlated with the duration of disease in the right rACC and PFC. Our results suggest that the resting-state abnormalities of these regions may be associated with functional impairments in pain processing in patients with migraine without aura. We hope that our results will improve the understanding of migraine. Copyright (C) 2011 John Wiley & Sons, Ltd.