Enantioselective and regioselective aza-Friedel-Crafts reaction of electron-rich phenols with isatin-derived ketimines
Enantioselective and regioselective aza-Friedel-Crafts reaction of electron-rich phenols with isatin-derived ketimines
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DOI：
10.1039/d0cc04966b
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发表时间：
2020-09-14
影响因子：
4.9
通讯作者：
Cheng, Jin-Pei
中科院分区：
文献类型：
--
作者：
Cai, Liu;Liu, Xiangshuai;Cheng, Jin-Pei
本文报道了一种有效的酚与靛红衍生的酮亚胺的不对称氮杂Friedel Crafts反应。在Bi（OH）（3）/CPA体系的催化下，合成了一系列手性3-氨基-2-羟吲哚，产率高达99%，对映选择性高达99%，区域选择性高达25/1。
An efficient asymmetric aza-Friedel-Crafts reaction of phenols with isatin-derived ketimines is described. The reaction, which was promoted by a Bi(OH)(3)/CPA system, gave a series of chiral 3-amino-2-oxindoles with high yields (up to 99%), excellent enantioselectivities (up to 99%) and moderate to very good regioselectivities (up to 25/1).