Review: Found in Translation: International Initiatives Pursuing Interleukin-1 Blockade for Treatment of Acute Kawasaki Disease.
Review: Found in Translation: International Initiatives Pursuing Interleukin-1 Blockade for Treatment of Acute Kawasaki Disease.
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评论：在翻译中发现：国际倡议追求白介素-1封锁治疗急性川崎病。
DOI：
10.1002/art.39975
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发表时间：
2017-02
期刊：
影响因子：
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通讯作者：
Arditi M
中科院分区：
文献类型：
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作者：
Burns JC;Koné-Paut I;Kuijpers T;Shimizu C;Tremoulet A;Arditi M
决定推进三项IL-1阻断治疗急性川崎病的临床试验是转化科学的一个案例研究。这些试验一方面来自急性疾病期间宿主反应的转录组研究，加上关键免疫信号传导途径的动物模型研究，另一方面，出于对急性川崎背景下严重炎症患者进行干预的临床绝望。实验室科学和临床观察的融合导致了这里描述的临床试验，并作为如何将这些观察转化为新疗法的模型。
The decision to move forward with three clinical trials of IL-1 blockade for treatment of acute Kawasaki disease is a case study in translational science. These trials were born on the one hand from transcriptome studies of host response during the acute disease coupled with animal model investigations of key immune signaling pathways and, on the other hand, out of clinical desperation to intervene in patients with severe inflammation in the setting of acute Kawasaki disease. The convergence of laboratory science and clinical observations led to the clinical trials described here and serves as a model for how such observations can be translated into new therapies.