Whole-brain 3D perfusion MRI at 3.0 T using CASL with a separate labeling coil
Whole-brain 3D perfusion MRI at 3.0 T using CASL with a separate labeling coil
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DOI：
10.1002/mrm.20124
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发表时间：
2004-07-01
影响因子：
3.3
通讯作者：
Chesnick, S
中科院分区：
文献类型：
--
作者：
Talagala, SL;Ye, FQ;Chesnick, S
近年来，各种连续和脉冲动脉自旋标记（ASL）灌注MRI技术已得到证实。这些方法仍然没有被常规使用的原因之一是成像区域的有限范围。在迄今为止提出的ASL方法中，具有单独标记线圈的连续ASL（CASL）对于高场下的全脑研究特别有吸引力。这种方法可以在灌注图像中提供增加的信噪比（SNR），因为没有磁化传递（MT）效应，并且减少了对高场RF功率沉积的担忧，因为它使用了局部标记线圈。在这项工作中，我们证明了CASL全脑定量灌注成像在3.0 T的组合使用的策略：三维体积采集，背景组织信号抑制，和一个单独的标记线圈。结果表明，该方法可以用于获得所有脑区的灌注图像，具有良好的灵敏度。此外，它表明，该方法可以安全地对人类进行，而不超过目前的RF功率沉积限制。当前的方法可以扩展到更高的场，并且通过使用多个接收器线圈和并行成像技术来进一步改进，以减少扫描时间或提供增加的分辨率。
A variety of continuous and pulsed arterial spin labeling (ASL) perfusion MRI techniques have been demonstrated in recent years. One of the reasons these methods are still not routinely used is the limited extent of the imaging region. Of the ASL methods proposed to date, continuous ASL (CASL) with a separate labeling coil is particularly attractive for whole-brain studies at high fields. This approach can provide an increased signal-to-noise ratio (SNR) in perfusion images because there are no magnetization transfer (MT) effects, and lessen concerns regarding RF power deposition at high field because it uses a local labeling coil. In this work, we demonstrate CASL whole-brain quantitative perfusion imaging at 3.0 T using a combination of strategies: 3D volume acquisition, background tissue signal suppression, and a separate labeling coil. The results show that this approach can be used to acquire perfusion images in all brain regions with good sensitivity. Further, it is shown that the method can be performed safely on humans without exceeding the current RF power deposition limits. The current method can be extended to higher fields, and further improved by the use of multiple receiver coils and parallel imaging techniques to reduce scan time or provide increased resolution.