Dexamethasone alters vascular reactivity by enhancing COX-related vasodilatation in fetal ovine carotids.
Dexamethasone alters vascular reactivity by enhancing COX-related vasodilatation in fetal ovine carotids.
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地塞米松通过增强胎羊颈动脉中 COX 相关的血管舒张来改变血管反应性。
DOI：
10.1159/000090340
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发表时间：
2006
期刊：
影响因子：
--
通讯作者：
Pearce,WilliamJ
中科院分区：
文献类型：
--
作者：
Angeles,DanilynM;Chang,Melody;Leong,Valerie;Oberg,KerbyC;Pearce,WilliamJ
根据初步研究，收缩效力改变新生儿供体的椎动脉和基底动脉与出生后糖皮质激素治疗，我们检查的假设，出生后地塞米松（DEX），用于呼吸系统疾病的新生儿，可以改变血管反应性的糖皮质激素。使用近足月胎儿羔羊颈动脉，我们测量了5-羟色胺（5-HT）在DEX处理和未处理动脉中的剂量-反应关系。我们发现，DEX孵育1小时对5-HT敏感性和激动剂亲和力没有影响，但显着降低5-HT收缩功效，DEX处理4小时后，反应变得更加明显。DEX处理的动脉与INDO共孵育4小时逆转了DEX诱导的5-HT收缩效力衰减，尽管DEX对环氧合酶（考克斯）-1和考克斯-2蛋白丰度没有显著影响。这些数据表明，DEX通过COX相关机制改变血管反应性，可能对神经损伤产生影响。
Based on preliminary studies that contractile efficacy was altered in vertebral and basilar arteries from neonatal donors treated with postnatal glucocorticoids, we examined the hypothesis that postnatal dexamethasone (DEX), a glucocorticoid used for respiratory disease in neonates, can alter vascular reactivity. Using near-term fetal lamb carotids, we measured 5-hydroxytryptamine (5-HT) dose-response relationship in DEX-treated and untreated arteries. We found that DEX incubation for 1 h had no effect on 5-HT sensitivity and agonist affinity but significantly reduced 5-HT contractile efficacy, a response that became even more pronounced after 4 h of DEX treatment. Coincubation of DEX-treated arteries with INDO for 4 h reversed this DEX-induced attenuation in 5-HT contractile efficacy, although DEX had no significant effects on cyclooxygenase (COX)-1 and COX-2 protein abundance. This data suggests that DEX alters vascular reactivity through a COX-related mechanism, with possible repercussions to neurological injury.