Individual Differences in Fear Potentiated Startle in Behaviorally Inhibited Children
Individual Differences in Fear Potentiated Startle in Behaviorally Inhibited Children
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DOI：
10.1002/dev.21096
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发表时间：
2014-01-01
影响因子：
2.2
通讯作者：
Fox, Nathan A.
中科院分区：
文献类型：
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作者：
Barker, Tyson V.;Reeb-Sutherland, Bethany C.;Fox, Nathan A.
行为抑制（BI）是一种气质，其特征是在儿童早期对新奇事物的恐惧增加，对不熟悉的同龄人保持社交沉默，以及焦虑发展的风险增加。在患有焦虑症的行为抑制青少年中发现，对安全线索的惊吓反应增强，这表明该措施可以作为该风险人群焦虑发展的生物标志物。然而，目前尚不清楚这些异常的惊吓模式是否出现在这一气质群体的焦虑表现之前。本研究探讨了7岁儿童的强化惊吓，其特征是BI在生命早期。高行为抑制的儿童表现出增加惊吓幅度的安全线索，特别是在前半年的任务，和更快的惊吓反应相比，低行为抑制的儿童。这些研究结果表明，异常惊吓反应是明显的行为抑制儿童在儿童早期发病前的障碍，并可能作为一个可能的内表型焦虑的发展。(c)2013 Wiley Periodicals，Inc. Dev Psychobiol 56：133-141，2014.
Behavioral inhibition (BI) is a temperament characterized during early childhood by increased fearfulness to novelty, social reticence to unfamiliar peers, and heightened risk for the development of anxiety. Heightened startle responses to safety cues have been found among behaviorally inhibited adolescents who have an anxiety disorder suggesting that this measure may serve as a biomarker for the development of anxiety amongst this risk population. However, it is unknown if these aberrant startle patterns emerge prior to the manifestation of anxiety in this temperament group. The current study examined potentiated startle in 7-year-old children characterized with BI early in life. High behaviorally inhibited children displayed increased startle magnitude to safety cues, particularly during the first half of the task, and faster startle responses compared to low behaviorally inhibited children. These findings suggest that aberrant startle responses are apparent in behaviorally inhibited children during early childhood prior to the onset of a disorder and may serve as a possible endophenotype for the development of anxiety. (c) 2013 Wiley Periodicals, Inc. Dev Psychobiol 56: 133-141, 2014.