Impact of prebiotic supplementation on T-cell subsets and their related cytokines, anthropometric features and blood pressure in patients with type 2 diabetes mellitus: A randomized placebo-controlled Trial
Impact of prebiotic supplementation on T-cell subsets and their related cytokines, anthropometric features and blood pressure in patients with type 2 diabetes mellitus: A randomized placebo-controlled Trial
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DOI：
10.1016/j.ctim.2015.12.010
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发表时间：
2016-02-01
影响因子：
3.6
通讯作者：
Akbari, Aliakbar Movasaghpour
中科院分区：
文献类型：
--
作者：
Dehghan, Parvin;Farhangi, Mandieh Abbasalizad;Akbari, Aliakbar Movasaghpour
背景和目标：2型糖尿病（T2 DM）是糖尿病发病和死亡的主要原因之一，与免疫系统紊乱和代谢异常有关。本研究旨在评价富含低聚果糖的菊粉对2型糖尿病患者T细胞亚群及其相关细胞因子、人体测量和代谢指标的影响。方法：46例女性糖尿病患者随机分为干预组（n=27）和对照组（n = 22）。干预组受试者每天接受10 g富含低聚果糖的菊粉，对照组受试者接受安慰剂，持续两个月。在治疗开始和2个月后测量人体测量学指标、代谢指标包括空腹血糖（FSG）、血红蛋白Alc（HbAlc）、血脂和血压。免疫标志物还包括血清白细胞介素（IL）-4、IL-12和干扰素（IFN）-γ浓度，并在基线和试验结束时通过流式细胞术测定CD 3 *、CD 4（+）、CD 8（+）和CD 11b（+）T细胞计数。经过两个月的干预，人体测量变量有了显著改善，益生元治疗组血压、血脂均明显下降（P< 0.001）。干预组血清IL-4、IL-12和IFN-γ水平也明显降低（P< 0.001）。干预后治疗组CD 3（+）、CD 4（+）、CD 8（+）和CD 11b * T细胞计数无显著变化。结论：本研究显示了富含低聚果糖的菊粉对改善T2 DM患者的血糖状态、血脂和免疫指标的有益作用。需要进一步的研究来证实我们的发现，并更好地阐明潜在的机制。(C)2015爱思唯尔有限公司版权所有。
Backgrounds and aims: Type 2 diabetic mellitus (T2DM) asone of the main causes of morbidity and mortality is associated with immune system disturbances and metabolic abnormalities. In the current study we aimed to evaluate the effects of oligofructose-enriched inulin on T-cell subsets and their related cytokines, anthropometric and metabolic parameters in patients with T2DM.Methods: Forty-six diabetic females patients were randomly allocated into intervention (n=27) and control (n = 22) groups. Subjects in the intervention group received a daily dose of 10 g of oligofructose-enriched inulin and subjects in control group received a placebo for two months. Anthropometric variables, metabolic parameters including fasting serum glucose (FSG), hemoglobin Al c (HbAlc), lipid profile and blood pressure were measured at the beginning and after two months. Immune markers also included serum interleukin (IL) -4, IL -12 and interferon (IFN)-gamma concentrations were assessed and CD3*, CD4(+), CD8(+) and CD11b(+)T-cell counts were determined by flow cytometry at baseline and end of the trial.Results: After two months intervention, significant improvements in anthropometric variables, blood pressure and serum lipids occurred in prebiotic-treated group (P< 0.001). Serum IL -4, IL -12 and IFN-gamma concentrationsalso significantly decreased in intervention group (P< 0.001). No significant changes in CD3(+), CD4(+), CD8(+) and CD11b* T-cell counts were observed in treatment groups after intervention.Conclusion: The present study showed several beneficial effects of oligofructose-enriched inulin on the improvement of the glycemic status, lipid profile, and immune markers in patients with T2DM. Further studies are needed to confirming our findings and to better clarify the underlying mechanisms. (C) 2015 Elsevier Ltd. All rights reserved.