Cell death in the pathogenesis of immune-mediated diseases: the role of HMGB1 and DAMP-PAMP complexes.
Cell death in the pathogenesis of immune-mediated diseases: the role of HMGB1 and DAMP-PAMP complexes.
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DOI：
10.4414/smw.2011.13256
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发表时间：
2011
影响因子：
2.9
通讯作者：
Pisetsky D
中科院分区：
文献类型：
--
作者：
Pisetsky D
细胞死亡是一个普遍存在的过程，其免疫学后果可以影响感染性、自身免疫性和炎性疾病的进程。虽然细胞死亡长期以来被分为凋亡和坏死，但其他形式的死亡也可能发生，并且在刺激和抑制炎症的能力方面有所不同。死亡细胞的促炎活性来自于在死亡期间随着细胞渗透性破坏而释放的多种细胞内分子。这些分子被称为DAMP（损伤相关分子模式）或警报素。在这些DAMP中，HMGB1，一种非组蛋白核蛋白，作为原型。虽然HMGB1最初被认为是单独作为一种细胞因子，但最近的研究表明，它的免疫效应是由HMGB1与其他DAMP或PAMP（病原体相关分子模式）的复合物引起的。总之，关于HMGB1在发病机制中的作用的研究表明，细胞外复合物的形成是细胞死亡期间产生促炎信号的重要机制，因此是新疗法的潜在靶点。
Cell death is a ubiquitous process whose immunological consequences can influence the course of infectious, autoimmune and inflammatory diseases. While cell death was long dichotomized in terms of apoptosis and necrosis, other forms of death can occur and vary in their capacity to stimulate as well as inhibit inflammation. The pro-inflammatory activity of dead cells results from a wide variety of intracellular molecules that are released as cell permeability breaks during death. These molecules have been termed as DAMPs (damage associated molecular patterns) or alarmins. Among these DAMPs, HMGB1, a non-histone nuclear protein, serves as the prototype. Although HMGB1 was originally thought to act alone as a cytokine, recent studies suggest that its immunological effects result from complexes of HMGB1 with either other DAMPs or with PAMPs (pathogen associated molecular patterns). Together, studies on the role HMGB1 in pathogenesis suggest that the formation of extracellular complexes is an important mechanism for generating pro-inflammatory signals during cell death and therefore a potential target of new therapy.
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影响因子：
5.7
作者：
Antoine, Daniel James;Williams, Dominic P.;Park, B. Kevin
通讯作者：
Park, B. Kevin
影响因子：
4.4
作者：
Morimoto, Konosuke;Janssen, William J.;Vandivier, R. William
通讯作者：
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影响因子：
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作者：
Li, JH;Wang, HC;Yang, H
通讯作者：
Yang, H
DOI：
10.1083/jcb.201004096
发表时间：
2010-06-28
期刊：
The Journal of cell biology
影响因子：
--
作者：
Elliott MR;Ravichandran KS
通讯作者：
Ravichandran KS
影响因子：
5.5
作者：
Bell, Charles W.;Jiang, Weiwen;Pisetsky, David S.
通讯作者：
Pisetsky, David S.