Acute Fibrinous and Organizing Pneumonia Associated With Allogenic Hematopoietic Stem Cell Transplant Successfully Treated With Corticosteroids: A Two-Patient Case Series.
Acute Fibrinous and Organizing Pneumonia Associated With Allogenic Hematopoietic Stem Cell Transplant Successfully Treated With Corticosteroids: A Two-Patient Case Series.
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DOI：
10.1177/2324709616643990
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发表时间：
2016-04
影响因子：
1.2
通讯作者：
Harper R
中科院分区：
文献类型：
--
作者：
Nguyen LP;Ahdoot S;Sriratanaviriyakul N;Zhang Y;Stollenwerk N;Schivo M;Harper R
急性纤维蛋白和机化性肺炎(AFOP)是一种极为罕见的、相对较新的、独特的急性肺损伤的组织学类型，其主要特征是肺泡内纤维蛋白的存在和相关的机化性肺炎。AFOP可能是特发性的，也可能与多种临床症状相关。它的临床表现多种多样，从轻微的呼吸道症状到类似急性呼吸窘迫综合征。目前还没有关于治疗的共识，皮质类固醇之前的益处也不清楚。到目前为止，文献中报道的AFOP病例不到40例，只有一例与造血干细胞移植有关。在这里，我们报告了第一个病例系列，两名患者在异基因干细胞移植后发生AFOP，并成功地使用了大剂量皮质类固醇治疗。
Acute fibrinous and organizing pneumonia (AFOP) is an extremely rare, relatively new, and distinct histological pattern of acute lung injury characterized predominately by the presence of intra-alveolar fibrin and associated organizing pneumonia. AFOP may be idiopathic or associated with a wide spectrum of clinical conditions. It has a variable clinical presentation from mild respiratory symptoms to that similar to the acute respiratory distress syndrome. Currently there is no consensus on treatment, and corticosteroids previously were of unclear benefit. To date, there are less than 40 cases of AFOP reported in the literature and only one has been linked to hematopoietic stem cell transplantation. Here we report the first case series of 2 patients who developed AFOP following allogenic stem cell transplant that were successfully treated with high-dose corticosteroids.