Individual differences in the heart rate response to activation of the muscle metaboreflex in humans.
Individual differences in the heart rate response to activation of the muscle metaboreflex in humans.
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DOI：
10.1152/ajpheart.00255.2010
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发表时间：
2010-11
期刊：
影响因子：
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通讯作者：
Kazuhito Watanabe;M. Ichinose;Naoto Fujii;Mayumi Matsumoto;T. Nishiyasu
中科院分区：
文献类型：
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作者：
Kazuhito Watanabe;M. Ichinose;Naoto Fujii;Mayumi Matsumoto;T. Nishiyasu
我们验证了以下假设：运动后肌肉缺血（PEMI）引起的肌肉代谢反射激活引起的心率（HR）反应在受试者之间有很大差异，并且心率反应的个体差异与PEMI期间心脏自主神经张力和/或动脉压力反射功能的差异有关。51名健康受试者（36名男性和15名女性）在50%的最大自主收缩下进行1分钟的等距握力锻炼，随后进行3.5分钟的强制PEMI。我们使用R-R间期（RRI）搏动变化的频谱分析来估计心脏自主神经张力。此外，通过收缩压（SAP）和RRI的传递函数分析来评价动脉压反射控制HR （BRS）的敏感性。尽管在PEMI期间和随后的恢复期的平均RRI与静息值没有差异，但休息和PEMI期间RRI的个体差异差异显著大于休息和恢复期。PEMI引起的RRI变化与高频范围内RRI变异性的谱功率变化和BRS显著相关。相比之下，RRI的变化与平均动脉压的变化或低频范围内RRI变异性的强弱之间没有明显的相关性。这表明，在人类中，心肌对PEMI诱导的肌肉代谢反射激活的反应在个体之间有很大差异，这些差异反映了PEMI期间心脏副交感神经张力和自发BRS的变化。
We tested the hypotheses that the heart rate (HR) response to muscle metaboreflex activation induced by postexercise muscle ischemia (PEMI) varies considerably among subjects and that individual differences in the HR response are associated with differences in cardiac autonomic tone and/or arterial baroreflex function during PEMI. Fifty-one healthy subjects (36 men and 15 women) performed a 1-min isometric handgrip exercise at 50% maximal voluntary contraction, which was followed by a 3.5-min period of imposed PEMI. We estimated cardiac autonomic tone using spectral analysis of beat-to-beat variation in the R-R interval (RRI). In addition, the sensitivity of the arterial baroreflex control of HR (BRS) was evaluated using transfer function analysis of systolic arterial pressure (SAP) and RRI. Although the mean RRI during the PEMI and subsequent recovery period did not differ from the resting value, the variance among the individual differences in RRI between the rest and PEMI periods was significantly greater than between the rest and recovery periods. The changes in RRI elicited by PEMI correlated significantly with changes in the spectral power of the RRI variability in the high-frequency range and the BRS. By contrast, no significant correlation was observed between changes in RRI and changes in mean arterial pressure or the power of the RRI variability in the low-frequency range. This suggests that, in humans, the HR response to PEMI-induced activation of muscle metaboreflex varies considerably from individual to individual and that these differences reflect changes in cardiac parasympathetic tone and spontaneous BRS during PEMI.