Expressions of CXCR7/ligands may be involved in oral carcinogenesis
Expressions of CXCR7/ligands may be involved in oral carcinogenesis
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DOI：
10.1007/s10735-011-9322-x
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发表时间：
2011-04-01
影响因子：
3.2
通讯作者：
Cheng, Bin
中科院分区：
文献类型：
--
作者：
Xia, Juan;Wang, Juan;Cheng, Bin
口腔癌的发生是一个多步骤的过程，需要一系列分子事件的积累和相互作用。趋化因子及其受体在肿瘤的发生和发展中起重要作用。目前，还没有关于它们在口腔鳞状细胞癌（OSCC）癌前病变中的变化的报道。基因芯片检测结果显示，口腔白斑（OLK）组织中9种趋化因子和包括CXCR 7在内的3种趋化因子受体的mRNA表达水平均高于正常组织2倍以上。然后，选择CXCR 7进行进一步确认和免疫组化检测在多阶段口腔癌的发生。CXCR 7在85%的OLK和86%的OSCC中表达。然而，只有8%（1/13例）的正常组织显示CXCR 7免疫染色。CXCR 7、CXCL 12和CXCL 11在口腔白斑和口腔鳞癌中的阳性表达率均显著高于正常口腔黏膜（P < 0.05），但在口腔白斑和口腔鳞癌中的表达率无显著性差异。同时，CXCR 7在OLK和OSCC组织中总是与其配体同时表达。提示CXCR 7-CXCL 12/CXCL 11轴可能在口腔癌的发生发展中起重要作用。
Oral carcinogenesis is a multistep process and requires accumulation and interplay of a series of molecular events. Chemokines and their receptors have been suggested to play important roles in the initiation or progression of cancers. Until now, no report focuses on their alterations in premalignant stage of oral squamous cell carcinoma (OSCC). Compared with normal tissues, mRNA levels of 9 chemokines and 3 chemokine receptors including CXCR7 in oral leukoplakia (OLK) were increased more than two folds by microarray analysis. Then, CXCR7 was selected for further confirmation and immunohistochemistry examination during multistage oral carcinogenesis. CXCR7 was expressed in 85% of OLK and 86% of OSCC. However, only 8% (1 of 13 cases) of normal tissue displayed CXCR7 immunostaining. The positive ratios of CXCR7, CXCL12 and CXCL11 in OLK and OSCC tissues respectively, were significantly higher than that in normal epithelia (P < 0.05), although no significant difference was found between OLK and OSCC. Meanwhile, CXCR7 always concomitantly expressed with it ligands in OLK and OSCC tissues. Our results indicated that CXCR7-CXCL12/CXCL11 axis might play important roles in oral carcinogenesis.