The Non-Small Cell Lung Cancer Immune Contexture A Major Determinant of Tumor Characteristics and Patient Outcome
The Non-Small Cell Lung Cancer Immune Contexture A Major Determinant of Tumor Characteristics and Patient Outcome
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DOI：
10.1164/rccm.201409-1671pp
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发表时间：
2015-02-15
影响因子：
24.7
通讯作者：
Gnjatic, Sacha
中科院分区：
文献类型：
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作者：
Remark, Romain;Becker, Christian;Gnjatic, Sacha
实体瘤不仅仅是癌细胞的积累，还形成了一个复杂的生态系统，由正常上皮细胞、成纤维细胞、血管和淋巴管、结构成分和浸润性造血细胞组成，包括影响肿瘤生长、肿瘤扩散和临床结果的骨髓和淋巴成分。免疫微环境的组成是多样的，包括T细胞、B细胞、树突细胞、自然杀伤细胞、骨髓源性抑制细胞、嗜中性粒细胞或巨噬细胞的各种群体。免疫结构描述了实体瘤中这些免疫细胞的密度、位置和组织。在肺癌中，这是最致命的癌症类型，特别是在非小细胞肺癌中，其最普遍的形式，报告描述了肿瘤和宿主之间的一些相互作用。这些数据，以及关于各种类型肿瘤的文章，提供了对肿瘤-宿主微环境相互作用的更好理解，并刺激了预后和预测生物标志物的发展，识别用于治疗干预的新型靶抗原，以及实施癌症患者长期管理的工具。
Solid tumors, beyond mere accumulation of cancer cells, form a complex ecosystem consisting of normal epithelial cells, fibroblasts, blood and lymphatic vessels, structural components, and infiltrating hematopoietic cells including myeloid and lymphoid elements that impact tumor growth, tumor spreading, and clinical outcome. The composition of the immune microenvironment is diverse, including various populations of T cells, B cells, dendritic cells, natural killer cells, myeloid-derived suppressor cells, neutrophils, or macrophages. The immune contexture describes the density, location, and organization of these immune cells within solid tumors. In lung cancer, which is the deadliest type of cancer, and particularly in non-small cell lung cancer, its most prevalent form, reports have described some of the interactions between the tumor and the host. These data, in addition to articles on various types of tumors, provide a greater understanding of the tumor-host microenvironment interaction and stimulate the development of prognostic and predictive biomarkers, the identification of novel target antigens for therapeutic intervention, and the implementation of tools for long-term management of patients with cancer.