GRAFT DONOR SELECTION BASED UPON SINGLE LOCUS (HAPLOTYPE) ANALYSIS WITHIN FAMILIES
GRAFT DONOR SELECTION BASED UPON SINGLE LOCUS (HAPLOTYPE) ANALYSIS WITHIN FAMILIES
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DOI：
10.1097/00007890-196807000-00003
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发表时间：
1968-01-01
期刊：
影响因子：
6.2
通讯作者：
SEIGLER, HF
中科院分区：
文献类型：
--
作者：
AMOS, B;WARD, FE;SEIGLER, HF
可以根据家族对HL-A系统的遗传单位（单倍型）的遗传对家族进行基因分型。已经证实了在HL-A基因型相同的兄弟姐妹之间交换皮肤的结论是可以接受的。单倍型的抗原性可以通过同胞之间的皮肤移植来确定。一些单倍型被迅速反应，其他单倍型引起的影响很小，但可能是有效的组合。一个可能的重组被确认血清学。皮肤移植物的排斥反应次数加强了这一假设。建议通过（a）皮肤移植和（B）产生针对重组单倍型的抗体来确认重组，并开始连锁图。
Families can be genotyped with respect to their inheritance of the units of inheritance of the HL-A system (haplotypes). The conclusion that skin exchanged between siblings who are genotypically identical with respect to HL-A is accepted for prolonged periods has been confirmed. The antigenicity of a haplotype can be determined by skin transplantation between siblings. Some haplotypes are rapidly reacted against, others elicit little effect alone but may be effective in combination. A possible recombinant was recognized serologically. The hypothesis was strengthened by the rejection times of skin grafts. Guidelines are suggested for the confirmation of recombination by (a) skin grafting and (b) the production of antibodies against the recombinant haplotypes, and for starting a linkage map.