Mechanical properties of asthmatic airway smooth muscle
Mechanical properties of asthmatic airway smooth muscle
复制标题
DOI：
10.1183/09031936.00065411
复制
发表时间：
2012-07-01
影响因子：
24.3
通讯作者：
Pare, Peter D.
中科院分区：
文献类型：
--
作者：
Chin, Leslie Y. M.;Bosse, Ynuk;Pare, Peter D.
气道平滑肌（ASM）是哮喘气道过度狭窄的主要效应器。ASM的某些机械性能的变化可能会导致过度狭窄，并没有系统地研究在人类ASM从nonasthma和asthma subjects.Human ASM条（8哮喘和6 nonasthma）进行了研究，在原位长度和力归一化电场刺激（EFS）诱导的最大力。测量包括：长度适应前后的被动力和主动力与长度的关系、力-速度关系、最大缩短和长度振荡后的力恢复。通过除以肌肉的横截面积将力转换为应力。唯一的功能差异是哮喘组织在较长的长度上更僵硬（p
Airway smooth muscle (ASM) is the major effector of excessive airway narrowing in asthma. Changes in some of the mechanical properties of ASM could contribute to excessive narrowing and have not been systematically studied in human ASM from nonasthmatic and asthmatic subjects.Human ASM strips (eight asthmatic and six nonasthmatic) were studied at in situ length and force was normalised to maximal force induced by electric field stimulation (EFS). Measurements included: passive and active force versus length before and after length adaptation, the force-velocity relationship, maximal shortening and force recovery after length oscillation. Force was converted to stress by dividing by cross-sectional area of muscle.The only functional differences were that the asthmatic tissue was stiffer at longer lengths (p