Common data elements for predictors of pediatric sepsis: A framework to standardize data collection.
Common data elements for predictors of pediatric sepsis: A framework to standardize data collection.
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DOI：
10.1371/journal.pone.0253051
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发表时间：
2021
期刊：
影响因子：
3.7
通讯作者：
Ansermino M
中科院分区：
文献类型：
--
作者：
Mawji A;Li E;Chandna A;Kortz T;Akech S;Wiens MO;Kissoon N;Ansermino M
儿童败血症预测因素的标准化收集具有巨大的潜力，可以提高研究数据的兼容性。儿科脓毒症预测器标准化工作组合作定义了分诊时儿科脓毒症预测器的通用数据元素，作为资源有限环境下数据收集的标准化框架。通过系统的文献回顾和全球指南文件的检查，编制了一份初步的儿科脓毒症预测变量清单。一个涉及独立投票和积极小组讨论的5轮修正德尔菲进行了选择，标准化和优先级预测。考虑因素包括在分诊时候选预测器的感知预测值、内部和内部测量可靠性，以及在资源有限的情况下可靠地收集预测器所需的时间和物质资源。我们生成了116个通用数据元素，以便在未来的研究中实施。每个公共数据元素都包括一个标准化的提示、建议的响应值，以及按第1层（基本）、第2层（重要）或第3层（探索性）划分的优先级。将分支逻辑添加到预测器列表中，以促进高效数据收集方法的设计，例如移动应用程序上的低成本电子病例报告表单。这套通用数据元素可在儿科败血症CoLab Dataverse上免费获得，并可通过儿科败血症CoLab获得基于网络的反馈调查。根据儿科败血症研究界的反馈和新信息的出现，将不断发布更新的迭代。在未来的研究中常规使用公共数据元素可以允许研究之间的数据共享，并有助于开发强大的风险预测算法。在资源有限的情况下，这些算法可用于支持分诊时的临床决策。儿科败血症研究界的持续合作、参与和反馈对于确保公共数据元素在广泛的地理和社会文化环境中仍然适用非常重要。
Standardized collection of predictors of pediatric sepsis has enormous potential to increase data compatibility across research studies. The Pediatric Sepsis Predictor Standardization Working Group collaborated to define common data elements for pediatric sepsis predictors at the point of triage to serve as a standardized framework for data collection in resource-limited settings. A preliminary list of pediatric sepsis predictor variables was compiled through a systematic literature review and examination of global guideline documents. A 5-round modified Delphi that involved independent voting and active group discussions was conducted to select, standardize, and prioritize predictors. Considerations included the perceived predictive value of the candidate predictor at the point of triage, intra- and inter-rater measurement reliability, and the amount of time and material resources required to reliably collect the predictor in resource-limited settings. We generated 116 common data elements for implementation in future studies. Each common data element includes a standardized prompt, suggested response values, and prioritization as tier 1 (essential), tier 2 (important), or tier 3 (exploratory). Branching logic was added to the predictors list to facilitate the design of efficient data collection methods, such as low-cost electronic case report forms on a mobile application. The set of common data elements are freely available on the Pediatric Sepsis CoLab Dataverse and a web-based feedback survey is available through the Pediatric Sepsis CoLab. Updated iterations will continuously be released based on feedback from the pediatric sepsis research community and emergence of new information. Routine use of the common data elements in future studies can allow data sharing between studies and contribute to development of powerful risk prediction algorithms. These algorithms may then be used to support clinical decision making at triage in resource-limited settings. Continued collaboration, engagement, and feedback from the pediatric sepsis research community will be important to ensure the common data elements remain applicable across a broad range of geographical and sociocultural settings.
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DOI：
10.1177/1740774512438980
发表时间：
2012-06
期刊：
Clinical trials (London, England)
影响因子：
--
作者：
Grinnon ST;Miller K;Marler JR;Lu Y;Stout A;Odenkirchen J;Kunitz S
通讯作者：
Kunitz S
影响因子：
2.9
作者：
Chandna A;Aderie EM;Ahmad R;Arguni E;Ashley EA;Cope T;Dat VQ;Day NPJ;Dondorp AM;Illanes V;De Jesus J;Jimenez C;Kain K;Suy K;Koshiaris C;Lasry E;Mayxay M;Mondal D;Perera R;Pongvongsa T;Rattanavong S;Rekart M;Richard-Greenblatt M;Shomik M;Souvannasing P;Tallo V;Turner C;Turner P;Waithira N;Watson JA;Yosia M;Burza S;Lubell Y
通讯作者：
Lubell Y
影响因子：
2.9
作者：
Wooldridge, Gavin;Murthy, Srinivas;Kissoon, Niranjan
通讯作者：
Kissoon, Niranjan
影响因子：
38.9
作者：
Duenser, Martin W.;Festic, Emir;Schultz, Marcus J.
通讯作者：
Schultz, Marcus J.
影响因子：
120.7
作者：
Singer, Mervyn;Deutschman, Clifford S.;Angus, Derek C.
通讯作者：
Angus, Derek C.