Systems analysis of the prostate transcriptome in African-American men compared with European-American men
Systems analysis of the prostate transcriptome in African-American men compared with European-American men
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DOI：
10.2217/pgs-2016-0025
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发表时间：
2016-07-01
期刊：
影响因子：
2.1
通讯作者：
Gattoni-Celli, Sebastiano
中科院分区：
文献类型：
--
作者：
Hardiman, Gary;Savage, Stephen J.;Gattoni-Celli, Sebastiano
目的：非裔美国人(AA)比欧洲裔美国人(EA)有更高的前列腺癌风险和更高的死亡率。再生障碍性贫血是维生素D缺乏症的高发人群。我们检测了AA和EA患者的整体前列腺转录组，以及补充维生素D-3的效果。患者和方法：27名男性受试者(AA组10人，EA组17人)，拟接受前列腺切除术。14名受试者接受维生素D-3(每天4000IU)，13名受试者在手术前接受为期2个月的安慰剂治疗。结果：再生障碍性贫血患者免疫反应和炎症相关基因表达水平较高。结论：系统水平分析支持炎症过程可能促进再生障碍性贫血疾病进展的概念。这些转录本可以通过短期补充维生素D-3来调节。
Aim: African-Americans (AA) have increased prostate cancer risk and a greater mortality rate than European-Americans (EA). AA exhibit a high prevalence of vitamin D deficiency. We examined the global prostate transcriptome in AA and EA, and the effect of vitamin D-3 supplementation. Patients & methods: Twenty-seven male subjects (ten AA and 17 EA), slated to undergo prostatectomy were enrolled in the study. Fourteen subjects received vitamin D-3 (4000 IU daily) and 13 subjects received placebo for 2 months prior to surgery. Results: AA show higher expression of genes associated with immune response and inflammation. Conclusion: Systems level analyses support the concept that Inflammatory processes may contribute to disease progression in AA. These transcripts can be modulated by a short course of vitamin D-3 supplementation.