Glutathione S-transferase M1 and T1 polymorphism in men with idiopathic infertility
Glutathione S-transferase M1 and T1 polymorphism in men with idiopathic infertility
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DOI：
10.4238/vol8-3gmr642
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发表时间：
2009-01-01
影响因子：
0.4
通讯作者：
Moura, K. K. V. O.
中科院分区：
文献类型：
--
作者：
Finotti, A. C. F.;Costa e Silva, R. C. P.;Moura, K. K. V. O.
男性不育是一种异质性疾病，多种遗传和环境因素导致精子发生障碍。遗传因素导致了60%的特发性不孕症。编码第二阶段药物代谢解毒酶的基因的多态性可以改变它们的表达或功能，影响男性生殖系统暴露在有毒化合物中的生物转化。GSTM1和GSTT1编码的酶在内源性和外源性异物的解毒过程中是必不可少的，促进它们的排泄。我们检测了2004-2006年间在Goias联邦大学人类生殖服务中心发现的233例特发性不孕症患者的GSTM1和GSTT1基因多态性。GSTM1/T1(Null)基因型在30/105正常人和/128异常个体中检出，提示与特发性男性不育有显著关联。与GSTM1/T1(空)频率增加相关的精子改变是精子数量减少(少精子症)，这在GSTM1患者(78.9%)和GSTT1患者(73.7%)中更常见，但差异不显著。GSTM1和GSTT1基因的多态个体容易导致精子质量下降和不育症，这可能是因为少精子症个体受到GST多态的影响。
Male infertility is a heterogeneous disorder, with various genetic and environmental factors that contribute to the impairment of spermatogenesis. Genetic causes are responsible for 60% of cases of idiopathic infertility. Polymorphisms of genes that encode detoxifying enzymes of phase II drug metabolism can modify their expression or function, affecting the biotransformation of toxic compounds to which the male reproductive system is exposed. GSTM1 and GSTT1 encode enzymes that are essential in the process of detoxification of endogenous and exogenous xenobiotics, facilitating their excretion. We examined GSTM1 and GSTT1 polymorphism in 233 men with idiopathic infertility seen at the Human Reproduction Service of the Federal University of Goias from 2004-2006. Genotype GSTM1/T1 (null) was found in 30/105 normal individuals and in 64/128 abnormal individuals, indicating a significant association with idiopathic male infertility. The sperm alteration associated with greater GSTM1/T1 (null) frequency was decreased sperm count (oligozoospermy), which was more frequent in patients with GSTM1 (78.9%) as well as in those who had GSTT1 (73.7%), although the difference was not significant. Individuals polymorphic for genes GSTM1 and GSTT1 are susceptible to reduction in sperm quality and infertility, possibly because oligozoospermic individuals have been affected by GST polymorphism.