Expression of the insulin-like growth factor II gene in the choroid plexus and the leptomeninges of the adult rat central nervous system.
Expression of the insulin-like growth factor II gene in the choroid plexus and the leptomeninges of the adult rat central nervous system.
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胰岛素样生长因子 II 基因在成年大鼠中枢神经系统脉络丛和软脑膜中的表达。
DOI：
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发表时间：
1988
影响因子：
11.1
通讯作者：
A. Efstratiadis
中科院分区：
文献类型：
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作者：
F. Stylianopoulou;J. Herbert;M. Soares;A. Efstratiadis
大鼠胰岛素样生长因子II基因，编码胎儿生长调节素，在胚胎/胎儿组织和成人脑和脊髓中表达多转录物家族。通过对成人脑和脊髓的组织切片进行原位杂交，我们发现这些转录物不在神经细胞或神经胶质细胞中表达，但在每个脑室的脉络丛上皮和软脑膜中表达。我们认为脉络膜上皮细胞合成并分泌胰岛素样生长因子II进入脑脊液。
The rat insulin-like growth factor II gene, encoding a fetal somatomedin, expresses a multitranscript family in embryonic/fetal tissues and in the adult brain and spinal cord. By performing in situ hybridization on tissue sections of adult brain and spinal cord, we have found that these transcripts are not expressed in neural or glial cells but are expressed in the epithelium of the choroid plexus of each cerebral ventricle and in the leptomeninges. We propose that the choroidal epithelial cells synthesize and secrete insulin-like growth factor II into the cerebrospinal fluid.