Age-specific effects of novel mutations in Drosophila melanogaster II. Fecundity and male mating ability.
Age-specific effects of novel mutations in Drosophila melanogaster II. Fecundity and male mating ability.
复制标题
果蝇 II 中新突变的年龄特异性影响。
DOI：
10.1023/a:1017538505627
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发表时间：
2000
期刊：
影响因子：
1.5
通讯作者：
Promislow,DE
中科院分区：
文献类型：
--
作者：
Mack,PD;Lester,VK;Promislow,DE
衰老的进化理论假设存在具有年龄特异性效应的突变，但到目前为止，几乎没有实验证据支持这一假设。在这项研究中，我们让突变在黑腹果蝇的近交野生群体中积累，以测试雄性交配能力和繁殖力的年龄特异性差异。我们在 10、20 和 30 代突变积累后分析了突变对年龄的影响。对于交配能力，我们发现突变对 20 代后的前半生以及 30 代后几乎所有年龄的突变影响最强。这些结果与一项同伴研究的结果在定性上一致，该研究在相同的 D 品系上测定了年龄特异性死亡率。黑腹果蝇。相比之下，繁殖力的影响仅限于20代突变积累后的晚年，但到了30代，与雄性交配能力一样，新突变的影响分布在所有年龄组中。我们讨论了几种可能的解释，解释我们观察到的代际特征内和特征之间的差异，以及这些模式与衰老模型以及择偶和性选择模型的相关性。
Evolutionary theories of senescence assume that mutations with age-specific effects exist, yet until now, there has been little experimental evidence to support this assumption. In this study, we allowed mutations to accumulate in an outbred, wild population ofDrosophila melanogasterto test for age-specific differences in both male mating ability and fecundity. We assayed for age-specific effects of mutations after 10, 20, and 30 generations of mutation accumulation. For mating ability, we found the strongest effects of mutations in the first half of the life span after 20 generations, and at nearly all ages by generation 30. These results are qualitatively consistent with results from a companion study in which age-specific mortality was assayed on the same lines ofD. melanogaster. By contrast, effects of fecundity were confined to late ages after 20 generations of mutation accumulation, but by generation 30, as with male mating ability, effects of novel mutations were distributed across all age classes. We discuss several possible explanations for the differences that we observe between generations within traits, and among traits, and the relevance for these patterns to models of aging as well as models of mate choice and sexual selection.