Ruthenium-Catalyzed Synthesis of Fused Tricyclic 1H-2,3-Dihydropyrimido[1,2-a]quinolines in One Step
Ruthenium-Catalyzed Synthesis of Fused Tricyclic 1H-2,3-Dihydropyrimido[1,2-a]quinolines in One Step
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钌催化一步合成稠合三环1H-2,3-二氢嘧啶并[1,2-a]喹啉
DOI：
10.1021/acs.orglett.7b01330
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发表时间：
2017
期刊：
影响因子：
5.2
通讯作者：
Hu Yuefei
中科院分区：
文献类型：
--
作者：
Wang Xingyong;Liu Chulong;Zeng Xiaobao;Wang Xuesong;Wang Xinyan;Hu Yuefei
发展了一种新的Ru催化的腈和氮杂环化反应，实现了稠合三环1H-2，3-二氢嘧啶并[1，2-a]喹啉的一步合成。稠合的1H-2，3-二氢嘧啶并[1，2-a]喹啉是100多种天然吡喃的核心骨架，也是其荧光的来源。
A novel ruthenium-catalyzed intramolecular cyclization of a nitrile and an azetidine was developed to achieve a one-step synthesis of the fused tricyclic 1H-2,3-dihydropyrimido[1,2-a]quinoline, which is the core skeleton for more than 100 natural pyoverdines and is also responsible for their fluorescence.