TUMORIGENICITY OF FLUORANTHENE IN A NEWBORN MOUSE LUNG ADENOMA BIOASSAY
TUMORIGENICITY OF FLUORANTHENE IN A NEWBORN MOUSE LUNG ADENOMA BIOASSAY
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DOI：
10.1093/carcin/5.10.1311
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发表时间：
1984-01-01
期刊：
影响因子：
4.7
通讯作者：
WOGAN, GN
中科院分区：
文献类型：
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作者：
BUSBY, WF;GOLDMAN, ME;WOGAN, GN
采用新生小鼠24周肺腺瘤生物测定法，测定环境中常见的多环芳烃荧蒽的致瘤性。在用最高剂量（3.5 mg/小鼠）处理的动物中观察到肺肿瘤发生率升高6.5倍（58%）和数量增加12倍（1.08个肿瘤/小鼠），但700 μ g/小鼠未诱导肿瘤发生率增加。以相对低的剂量（280 μ g/小鼠）用作阳性对照的苯并[a]芘是高度有效的，在94%的动物中诱导肺肿瘤，并且使它们的数量增加44倍（4.0个肿瘤/小鼠）。大多数接受最高剂量苯并[a]芘（1.4 mg/小鼠）治疗的小鼠死于大面积注射部位肉瘤。在荧蒽和苯并[a]芘治疗组中存活24周的雄性小鼠发生了肺肿瘤，其肿瘤比接受荧蒽和苯并[a]芘治疗的雌性小鼠多2至3倍。这是首次报道的荧蒽致瘤性的证据。这些研究结果的意义方面的生物测定的灵敏度和对人类健康的影响进行了讨论。
A 24 wk lung adenoma bioassay using newborn mice was employed to determine the tumorigenicity of fluoranthene, a common environmental polynuclear aromatic hydrocarbon. A 6.5-fold elevation of lung tumor incidence (58%) and a 12-fold increase in numbers (1.08 tumors/mouse) was observed in animals treated with the highest dose (3.5 mg/mouse), but no increase in tumor incidence was induced by 700 .mu.g/mouse. Benzo[a]pyrene, used as a positive control at a comparatively low dose (280 .mu.g/mouse), was highly potent, inducing lung tumors in 94% of the animals and elevating their number by 44-fold (4.0 tumors/mouse). Most of the mice treated with the highest dose of benzo[a]pyrene (1.4 mg/mouse) died with massive injection site sarcomas. Male mice, surviving for 24 wk in fluoranthene and benzo[a]pyrene treatment groups that developed lung tumors, had 2- to 3-fold more tumors than comparably treated females. This is the first reported evidence of tumorigenicity of fluoranthene. The significance of these findings in terms of bioassay sensitivity and the implications regarding human health were discussed.