Changes in neuronal activity of the inferior colliculus in rat after temporal inactivation of the auditory cortex
Changes in neuronal activity of the inferior colliculus in rat after temporal inactivation of the auditory cortex
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DOI：
10.33549/physiolres.930355
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发表时间：
2003-01-01
影响因子：
2.1
通讯作者：
Syka, J
中科院分区：
文献类型：
--
作者：
Popelár, J;Nwabueze-Ogbo, FC;Syka, J
通过比较河豚毒素（TTX）对麻醉大鼠听觉皮质（AC）功能性消融前后下丘（IC）细胞外单细胞活性的变化，研究了皮质-顶叶通路在听觉信号处理中的作用。将16通道电极探头插入IC，同时记录几个IC神经元对声音刺激的反应。注射TTX后，从AC记录的点击诱发的中潜伏期反应（MLR）被抑制了几个小时。与对照组相比，在AC失活期间，IC神经元的放电率增加（40%的神经元），减少（44%）或不变（16%）。在一些IC神经元中，TTX注射导致速率水平功能形状的改变。在交流失活过程中，IC神经元的响应阈值、调谐特性和放电模式类型没有改变。然而，在三分之一的神经元中，反应的初始部分比后来持续的部分变化要小。在三分之二的神经元对中，功能性去皮导致相互关联系数的变化。结果揭示了同侧听觉皮层功能性消融后IC神经元活动出现的复杂变化。
The role of cortico-tectal pathways in auditory signal processing was studied in anesthetized rats by comparing the extracellular single unit activity in the inferior colliculus (IC) before and after functional ablation of the auditory cortex (AC) by tetrodotoxin (TTX). The responses of several IC neurons to sound stimuli were simultaneously recorded with a 16-channel electrode probe introduced into the IC. Click-evoked middle latency responses (MLR) recorded from the AC were suppressed for several hours after TTX injection. During AC inactivation the firing rate of IC neurons increased (40% of neurons), decreased (44%) or did not change (16%) in comparison with control conditions. In several IC neurons, TTX injection resulted in alterations in the shape of the rate-level functions. Response thresholds, tuning properties and the type of discharge pattern of IC neurons were not altered during AC inactivation. However, in one-third of the neurons, the initial part of the response was less altered than the later, sustained part. In two-thirds of neuronal pairs, functional decortication resulted in a change in the cross-correlation coefficient. The results reveal the complex changes that appear in IC neuronal activity after functional ablation of the ipsilateral auditory cortex.