Hypoxaemia in sickle cell disease: biomarker modulation and relevance to pathophysiology
Hypoxaemia in sickle cell disease: biomarker modulation and relevance to pathophysiology
复制标题
DOI：
10.1016/s0140-6736(03)14689-2
复制
发表时间：
2003-11-01
期刊：
影响因子：
168.9
通讯作者：
Allen, JL
中科院分区：
文献类型：
--
作者：
Setty, BNY;Stuart, MJ;Allen, JL
背景 夜间氧合血红蛋白去饱和可能在与镰状细胞病相关的中枢神经系统并发症以及疼痛危象发生率中发挥作用。我们试图检查生物学关系，并描述氧合血红蛋白去饱和的血液学危险因素。方法研究人群包括镰状细胞病儿童和对照儿童。通过测量可溶性血管细胞粘附分子 1、P-选择素、L-选择素和白三烯 B-4 来评估细胞活化。评估红细胞-内皮粘附和常规血液学变量。当儿童清醒和睡眠时，通过脉搏血氧仪测量血氧饱和度（SaO(2)）。平均睡眠 SaO(2) 小于或等于 93% 的儿童被确定为低氧血症。儿童被分为四组：对照组（10 名儿童）、HbSC（9 名，全部含氧量正常）、HbSS 含氧量正常 (13 名) 和 HbSS 低氧血症 (15 名)。 结果 在血液学变量中，睡眠 SaO(2) 仅与细胞堆积体积相关（r=0.7；p
Background Nocturnal oxyhaemoglobin desaturation might have a role in CNS complications related to sickle cell disease, and rates of painful crises. We attempted to examine the biological relations, and describe the haematological risk factors for oxyhaemoglobin desaturation.Methods The study population included children with sickle cell disease and controls. Cellular activation was assessed by measurement of soluble vascular cell adhesion molecule 1, P-selectin, L-selectin, and leukotriene B-4. Erythrocyte-endothelial adhesion and routine haematological variables were assessed. Oxygen saturation (SaO(2)) was measured by pulse oximetry while children were awake and asleep. Children with a mean sleeping SaO(2) of less than or equal to93% were identified as hypoxaemic. Children were divided into four groups: controls (ten children), HbSC (nine, all normoxic), HbSS normoxic (13), and HbSS hypoxaemic (15).Findings Among haematological variables, sleeping SaO(2) correlated only with packed-cell volume (r=0.7; p