Total and Regional Brain Volumes in a Population-Based Normative Sample from 4 to 18 Years: The NIH MRI Study of Normal Brain Development
Total and Regional Brain Volumes in a Population-Based Normative Sample from 4 to 18 Years: The NIH MRI Study of Normal Brain Development
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DOI：
10.1093/cercor/bhr018
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发表时间：
2012-01-01
期刊：
影响因子：
3.7
通讯作者：
Levitt, Jennifer
中科院分区：
文献类型：
--
作者：
Ball, William S.;Byars, Anna Weber;Levitt, Jennifer
利用基于人群的抽样策略，美国国立卫生研究院(NIH)正常脑发育磁共振成像研究编制了一个纵向的标准化参考数据库，其中包括神经成像和相关临床/行为数据，这些数据来自人口统计学上具有代表性的健康儿童和青少年样本，从新生儿到成年早期。本文报道了325名4.5-18岁儿童的第一个横断面时间点的脑体积数据。测量包括全脑灰质(GM)和白质(WM)、左右侧脑室、额叶、颞叶、顶叶和枕叶GM和WM、皮质下GM(丘脑、尾状核、壳核和苍白球)、小脑和脑干的体积。对横断面年龄、性别、家庭收入、父母教育程度和体重指数(BMI)的相关性进行了评估。主要的观察结果是：1)脑叶GM的年龄相关性下降，最显著的是顶叶和枕叶皮质；2)脑叶WM的年龄相关性增加，最大的是枕叶，其次是颞叶；3)年龄相关的轨迹主要是女性的曲线，但男性是线性的；4)脑组织体积与BMI的小系统关联，但与智商、家庭收入或父母教育无关。这些发现构成了儿童和青少年局部脑容量的规范性参考。
Using a population-based sampling strategy, the National Institutes of Health (NIH) Magnetic Resonance Imaging Study of Normal Brain Development compiled a longitudinal normative reference database of neuroimaging and correlated clinical/behavioral data from a demographically representative sample of healthy children and adolescents aged newborn through early adulthood. The present paper reports brain volume data for 325 children, ages 4.5-18 years, from the first cross-sectional time point. Measures included volumes of whole-brain gray matter (GM) and white matter (WM), left and right lateral ventricles, frontal, temporal, parietal and occipital lobe GM and WM, subcortical GM (thalamus, caudate, putamen, and globus pallidus), cerebellum, and brainstem. Associations with cross-sectional age, sex, family income, parental education, and body mass index (BMI) were evaluated. Key observations are: 1) age-related decreases in lobar GM most prominent in parietal and occipital cortex; 2) age-related increases in lobar WM, greatest in occipital, followed by the temporal lobe; 3) age-related trajectories predominantly curvilinear in females, but linear in males; and 4) small systematic associations of brain tissue volumes with BMI but not with IQ, family income, or parental education. These findings constitute a normative reference on regional brain volumes in children and adolescents.