Evaluation of 3.0-T MRI Brain Signal after Exposure to Gadoterate Meglumine in Women with High Breast Cancer Risk and Screening Breast MRI
Evaluation of 3.0-T MRI Brain Signal after Exposure to Gadoterate Meglumine in Women with High Breast Cancer Risk and Screening Breast MRI
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DOI：
10.1148/radiol.2019190847
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发表时间：
2019-12-01
期刊：
影响因子：
19.7
通讯作者：
Baltzer, Pascal A. T.
中科院分区：
文献类型：
--
作者：
Bennani-Baiti, Barbara;Krug, Barbara;Baltzer, Pascal A. T.
背景资料：乳腺癌高风险的健康女性每年接受造影剂增强乳腺MRI筛查检查，导致钆基造影剂（GBCA）的累积剂量较高。尽管大多数研究表明，在大环GBCA超过6次剂量后，脑深部核团的T1信号比没有增加，但这一点尚未在健康研究人群中进行探讨。目的：评估在高危乳腺癌筛查中使用大环GBCA累积剂量的女性是否表现出脑深部核团的T1改变。材料和方法：在2017年11月至2018年3月的这项前瞻性研究中，仅暴露于（由于高风险乳腺癌筛查）或未暴露于钆特酸葡胺的健康女性接受了3.0 T脑部MRI，使用专用头部线圈，包括T1标测和磁化准备的快速梯度回波序列。测量齿状核（DN）、苍白球（GP）、内囊前壁（CA）和脑桥的T1时间和T1信号强度。计算DN与脑桥和GP与CA的比值，并计算单变量Pearson相关系数。多变量分析包括偏回归分析。结果：本研究评估了25名女性（平均年龄，51岁+/- 11 [标准差]）暴露于平均GBCA剂量为129 mL（中位数112 mL;范围，70-302 mL）和16名女性（平均年龄，37岁+/- 10）从未暴露于任何GBCA。结果显示，GBCA累积剂量与T1时间或信号强度比之间无相关性（分别为P = 0.66和0.55）。在以年龄为混杂因素的偏相关分析中，GP/CA比值与GBCA剂量呈中度负相关（r = 20.40; P = .01），但GP T1时间不存在（r = 0.19; P = .24）。在给予相对大的累积剂量的钆特酸葡胺后，乳腺癌高危健康女性每年进行一次对比增强乳腺MRI筛查，在3.0-T MRI上，脑深部核团T1信号没有增加。(C)RSNA，2019年
Background: Otherwise healthy women at high risk for breast cancer undergo annual contrast agent-enhanced breast MRI screening examinations, resulting in high cumulative doses of gadolinium-based contrast agents (GBCAs). Whereas the majority of studies showed no T1 signal ratio increase in deep brain nuclei after more than six doses of macrocyclic GBCA, this has not been explored in a healthy study population.Purpose: To assess whether women who are administered large cumulative doses of macrocyclic GBCA with breast MRI at high-risk breast cancer screening exhibit T1 alterations in deep brain nuclei.Materials and Methods: In this prospective study from November 2017 to March 2018, healthy women who were either exposed (because of high-risk breast cancer screening) or unexposed to only gadoterate meglumine underwent 3.0-T brain MRI with a dedicated head coil, including T1 mapping and magnetization-prepared rapid gradient-echo sequences. T1 times and T1 signal intensities were measured in the dentate nucleus (DN), globus pallidus (GP), crus anterior of capsula interna (CA), and pons. Ratios of DN to pons and GP to CA were calculated, and univariable Pearson correlation coefficients were calculated. Multivariable analysis included partial regression analysis.Results: This study evaluated 25 women (mean age, 51 years +/- 11 [standard deviation]) who were exposed to a mean GBCA dose of 129 mL (median 112 mL; range, 70-302 mL) and 16 women (mean age, 37 years +/- 10) who were never exposed to any GBCA. Infratentorially, no correlation between cumulative GBCA dose and T1 times or signal intensity ratios was detected (P = .66 and .55, respectively). In partial correlation analysis by considering age as a confounder, there was a moderate negative correlation between GP-to-CA ratio and GBCA dose (r = 20.40; P = .01) but not for GP T1 times (r = 0.19; P = .24).Conclusion: After administration of relatively large cumulative doses of gadoterate dimeglumine, healthy women at high risk for breast cancer who underwent annual contrast-enhanced breast MRI screening did not exhibit T1 signal increase in deep brain nucleiat 3.0-T MRI. (C) RSNA, 2019