Mesolimbic dopamine mediates gastric mucosal protection by central neurotensin.
Mesolimbic dopamine mediates gastric mucosal protection by central neurotensin.
复制标题
DOI：
10.1152/ajpgi.1991.260.1.g34
复制
发表时间：
1991
期刊：
影响因子：
--
通讯作者：
L. Xing;C. Balaban;J. Seaton;J. Washington;G. Kauffman
中科院分区：
文献类型：
--
作者：
L. Xing;C. Balaban;J. Seaton;J. Washington;G. Kauffman
双侧伏核(NACB)和腹侧被盖区(VTA)微量注射神经降压素(NT；0.3、1.5和3.0微克/侧)，黑质和纹状体不注射(1.0微升/侧)，可减轻冷水束缚(CWR)2 h所致的胃粘膜损伤。NT诱导的保护作用的最小有效剂量直接进入NACB比进入侧脑室低10-100倍。这些作用可被直接注入NACB的多巴胺(DA)受体拮抗剂氟哌啶醇(Hal；0.5微克/侧)阻断。VTA内注射6-羟基多巴胺可耗尽内源性DA，并抑制NT预处理对CWR所致胃粘膜损伤的保护作用。在VTA和NACB内给予NT均可抑制五肽胃泌素刺激的胃酸分泌。这些结果表明，代表中脑边缘DA系统的VTA和NACB是NT和DA受体相互作用的重要部位，从而对CWR引起的胃粘膜损伤产生保护作用。
Bilateral microinjection (1.0 microliter/side) of neurotensin (NT; 0.3, 1.5, and 3.0 micrograms/side) into the nucleus accumbens (NACB) and ventral tegmental area (VTA) but not in substantia nigra and striatum reduced gastric mucosal injury produced by 2 h of cold-water restraint (CWR). The minimal effective dose for NT-induced protection was 10-100 times lower when administered directly into NACB than into the lateral ventricle. These effects were blocked by pretreatment with the dopamine (DA) receptor antagonist, haloperidol (Hal; 0.5 microgram/side) given directly into NACB. Injection of 6-hydroxydopamine into VTA depleted endogenous DA and inhibited gastric mucosal protection against CWR-induced injury afforded by NT pretreatment. NT, given into either VTA and NACB, inhibited pentagastrin-stimulated gastric acid secretion. These results suggest that VTA and NACB, which represent the mesolimbic DA system, are important locations for interaction between NT and DA receptors to produce gastric mucosal protection against CWR-induced injury.