Consumption of ω3-fatty acids during perinatal life:: role in immuno-modulation and allergy prevention
Consumption of ω3-fatty acids during perinatal life:: role in immuno-modulation and allergy prevention
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DOI：
10.1515/jpm.2007.031
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发表时间：
2007-01-01
影响因子：
2.4
通讯作者：
Renz, Harald
中科院分区：
文献类型：
--
作者：
Bluemer, Nicole;Renz, Harald
流行病学数据表明，饮食因素可能在最近过敏性疾病患病率增加中发挥了作用。一个与食物相关的成分可能是减少了ω 3-多不饱和脂肪酸的消耗，特别是在西方社会;然而，补充ω 3-脂肪酸的成人临床试验已建立过敏和支气管哮喘通常令人失望。然而，已知不成熟的免疫系统对免疫调节环境条件高度敏感，特别是在产前和产后时期。这篇综述讨论了在围产期阶段补充欧米茄3脂肪酸对儿童免疫系统的免疫调节作用。有证据表明，围产期ω 3-脂肪酸暴露影响新生儿的T细胞和抗原呈递细胞，可能是由于类花生酸代谢改变。虽然动物实验强烈表明母体ω 3-脂肪酸摄入对后代过敏性免疫反应的作用，但补充ω 3-脂肪酸的有益作用已在少数临床试验中进行了研究。在这些研究中，围产期补充剂对特应性综合征的不同临床表型有一定的积极作用。然而，需要更多的研究来充分探索围产期免疫调节的机会。
Epidemiological data suggest that dietary factors may have a role in recent increases of the prevalence of allergic diseases. One food-related component might be the reduced consumption of omega 3-polyunsaturated fatty acids observed especially in the Western societies; yet, clinical trials supplementing omega 3-fatty acids to adults with established allergies and bronchial asthma have generally been disappointing. However, it is known that the immature immune system is highly susceptible to immunomodulatory environmental conditions particularly in the pre- and postnatal period. This review discusses the immuno-modulatory effects of omega 3-fatty acids supplementation in the perinatal life phase on the immune system of the child. Evidence exists that perinatal w3-fatty acid exposure affects T-cells and antigen presenting cells of the neonates likely due to altered eicosanoid metabolism. Although animal experiments strongly suggest a role of maternal omega 3-fatty acid intake on allergic immune responses in the offspring, the beneficial effect of omega 3-fatty acid supplementation has been studied in a small number of clinical trials. In these studies perinatal supplementation had some positive effects on distinct clinical phenotypes of the atopic syndrome. However, more studies are needed to fully explore the opportunity of perinatal immuno-modulation.