Infusions of parathyroid hormone in ruminants: hypercalcemia and reduced plasma 1,25-dihydroxyvitamin D concentrations.
Infusions of parathyroid hormone in ruminants: hypercalcemia and reduced plasma 1,25-dihydroxyvitamin D concentrations.
复制标题
反刍动物输注甲状旁腺激素：高钙血症和血浆 1,25-二羟基维生素 D 浓度降低。
作者：
K. Hove;R. Horst;E. Littledike;D. Beitz
在八头小牛（150-230 公斤）和两只甲状腺甲状旁腺切除的山羊中研究了输注合成牛 PTH-(1-34) 与血浆中矿物质和维生素 D 代谢物浓度之间的关系。小牛用盐水静脉内输注15-20小时。然后，再给小牛注射三种溶液中的一种，持续 35 小时。八头小牛中的三头接受 3 ng/kg X 分钟（H 组），三头接受 0.75 ng/kg X 分钟（L 组），其余两只小牛在 33 小时内接受对照盐水（C 组）。每 4-6 小时采集一次血样。对照犊牛的血浆钙、磷、羟脯氨酸和 1,25-二羟基维生素 D [1,25-(OH)2D] 保持相对稳定。 H 组小牛输注 PTH 导致血浆钙从 2.4 增加到 3.0 mmol/L。 PTH输注不会引起血浆磷的变化，但会增加尿磷的排泄。输注 PTH 导致尿钙排泄适度增加，停药后出现明显的尿钙。 1,25-(OH)2D 的血浆浓度从输注开始时的约 30 pg/ml 降至输注结束时和此后 30 小时内不可检测的水平（低于 5 pg/ml）。 L组中观察到类似但不太明显的血浆钙和1,25-(OH)2D浓度的变化。甲状腺甲状旁腺切除术后两只泌乳山羊出现低钙血症和低磷血症，血浆1,25-(OH)2D浓度降低。 PTH 输注（3 ng/kg X 分钟）可纠正低钙血症和低磷血症，并显着升高血浆 1,25-(OH)2D 浓度。当除了 PTH 之外还输注氯化钙时，产生的高钙血症（3 mmol/升）与血浆 1,25-(OH)2D 显着降低有关。我们得出的结论是，当同时存在潜在冲突信号（例如高钙血症和高 PTH 浓度）时，血浆钙浓度对反刍动物血浆 1,25-(OH)2D 浓度具有主要调节作用。
The relationship between infused synthetic bovine PTH-(1-34) and plasma concentrations of minerals and vitamin D metabolites was studied in eight calves (150-230 kg) and two thyroparathyroidectomized goats. Calves were infused iv with saline for 15-20 h. Then, calves were infused with one of three types of solution for an additional 35-h period. Three of the eight calves received 3 ng/kg X min (group H), three received 0.75 ng/kg X min (group L), and the remaining two calves received control saline over a 33-h period (group C). Blood samples were taken every 4-6 h. Plasma calcium, phosphorus, hydroxyproline, and 1,25-dihydroxyvitamin D [1,25-(OH)2D] remained relatively constant in control calves. PTH infusions into calves in group H resulted in an increase in plasma calcium from 2.4 to a plateau of 3.0 mmol/liter. PTH infusion caused no change in plasma phosphorus, but increased urinary excretion of phosphorus. Infusion of PTH caused a moderate increase in urinary calcium excretion, followed by pronounced calciuria after PTH withdrawal. Plasma concentrations of 1,25-(OH)2D decreased from about 30 pg/ml at the start of infusion to undetectable levels (less than 5 pg/ml) at the end of the infusion and for 30 h thereafter. Similar, but less pronounced, changes in plasma calcium and 1,25-(OH)2D concentration were observed in group L. Hypocalcemia and hypophosphatemia developed in the two lactating goats after thyroparathyroidectomy, and plasma 1,25-(OH)2D concentrations were decreased. PTH infusion (3 ng/kg X min) corrected the hypocalcemia and hypophosphatemia and markedly raised plasma 1,25-(OH)2D concentrations. When calcium chloride was infused in addition to PTH, the resulting hypercalcemia (3 mmol/liter) was associated with a marked reduction in plasma 1,25-(OH)2D. We conclude that the concentration of calcium in plasma has the major regulatory role on plasma 1,25-(OH)2D concentrations in ruminant species when potentially conflicting signals, such as hypercalcemia and high PTH concentrations, are present simultaneously.
内源性生物活性人甲状旁腺激素：通过鸟苷酸扩增肾腺苷酸环化酶测定进行测量。
DOI：
10.1210/jcem-52-5-840
发表时间：
1981
期刊：
The Journal of clinical endocrinology and metabolism
影响因子：
--
作者：
Nissenson,RA;Abbott,SR;Teitelbaum,AP;Clark,OH;Arnaud,CD
通讯作者：
Arnaud,CD