Supplementary calcium in prevention of pre-eclampsia
Supplementary calcium in prevention of pre-eclampsia
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DOI：
10.1016/s0020-7292(01)00374-5
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发表时间：
2001-07-01
影响因子：
3.8
通讯作者：
Mosavi-Jarrahi, A
中科院分区：
文献类型：
--
作者：
Niromanesh, S;Laghaii, S;Mosavi-Jarrahi, A
目的：研究补钙对先兆子痫高危伊朗妇女减少先兆子痫的作用。方法：将30名有先兆子痫高危因素的孕妇随机分为两组，每日补钙2g，服用安慰剂。受试者和研究人员对治疗分配视而不见。纳入标准为翻身试验阳性，至少有一个PRL-子痫的危险因素。怀孕28至32周，且血压低于140/90(毫米汞柱)。排除标准是有任何慢性病。子痫前期定义为收缩压/舒张压超过140/90加上蛋白尿，所有受试者都被随访到分娩。结果：与安慰剂组相比，补钙组子痫前期的发生率降低了7倍(对照组15例中有7例发生子痫前期，钙组15例中有1例发生子痫前期，P=0.014)。未观察到对妊娠高血压综合征的重大影响(安慰剂组66%和钙组76%发生高血压)，但钙组高血压的发病时间推迟了3周。服用钙剂的孕妇比服用安慰剂的孕妇持续时间更长(平均+/-S.D.=37+/-2，服用安慰剂的孕妇为34+/-2，P<；0.05)。补钙组出生的婴儿平均比安慰剂组出生的婴儿重552g，P<；0.05，结论：补钙对伊朗有先兆子痫高危的妇女预防先兆子痫是有益的。(C)2001年国际妇产科联合会。版权所有。
Objective: To study the effect of calcium supplementation on reduction of pre-eclampsia in Iranian women at high risk of pre-eclampsia. Methods: Thirty pregnant women at high risk of developing pre-eclampsia were randomized to 2 g of daily calcium and placebo. Subjects and investigators were blinded to treatment allocation. The inclusion criteria were positive rollover test, having at least one risk factor for prl-eclampsia. between 28 and 32 weeks of pregnancy, and blood pressure less than 140/90 (mmHg). Exclusion criteria were having any chronic condition. Pre-eclampsia was defined as systolic/diastolic blood pressure over 140/90 plus proteinuria, All the subjects were followed up to delivery. Result: A sevenfold reduction in the occurrence of pre-eclamsia were seen among the calcium group compared with the placebo group (7 out of 15 developed pre-eclampsia in control group vs, 1 out of 15 in calcium group, P = 0.014). No major effect on pregnancy induced hypertension was seen (66% in placebo and 76% in calcium group developed hypertension) but the onset of hypertension was delayed 3 weeks in the calcium group. A Longer duration of pregnancy was seen in calcium than placebo (mean +/- S.D. = 37 +/- 2 for calcium and 34 +/- 2 for placebo, P < 0,05). Infants born to the calcium group, on average, were 552 g heavier than infants born to the placebo group, P < 0.05, Conclusion: Calcium supplementation is beneficial for preventing pre-eclampsia among Iranian women at high risk of developing pre-eclampsia. (C) 2001 International Federation of Gynecology and Obstetrics. All rights reserved.