COLLAGEN FABRICS AS BIOMATERIALS
COLLAGEN FABRICS AS BIOMATERIALS
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DOI：
10.1002/bit.260430813
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发表时间：
1994-04-05
影响因子：
3.8
通讯作者：
KRAUS, KH
中科院分区：
文献类型：
--
作者：
CAVALLARO, JF;KEMP, PD;KRAUS, KH
组织工程植入物需要适当的生物材料来服务于被修复或替换的组织所需的物理功能，同时促进植入物的重塑。我们报道了由连续胶原蛋白线制成的可植入织物的发展。胶原线是通过将天然酸提取的牛胶原挤出聚乙二醇缓冲溶液，然后冲洗和风干而形成的。这种线的高制造率允许生产各种结构的胶原蛋白织物。纤维直径可控制，可生产干径低至25 μ m的螺纹。在犬模型中植入作为前交叉韧带替代物的辫子和胶原蛋白束在12周后完全重塑成宿主组织。在大鼠腹部修复模型中植入针织胶原纤维织物可防止疝出，并在织物内观察到结缔组织长入12周。(C) 1994 John Wiley and Sons, Inc。
Tissue-engineered implants require appropriate biomaterials to serve the required physical function of the tissue being repaired or replaced while facilitating remodeling of the implant. We report on the development of implantable fabrics manufactured from continuous collagen threads. The collagen threads are formed by extrusion of native, acid-extracted bovine collagen into a buffered solution of polyethylene glycol, followed by rinsing and air drying. The high manufacturing rate of such threads permits the production of collagen fabrics of various configurations. The fiber diameter can be controlled, and threads with dry diameters as low as 25 mu m have been produced. Braids and bundles of collagen threads implanted as a replacement of the anterior cruciate ligament in a dog model were completely remodeled into host tissue by 12 weeks. Knitted collagen fabrics implanted in a rat abdominal repair model prevented herniation, and connective tissue ingrowth was observed within the fabric by 12 weeks. (C) 1994 John Wiley and Sons, Inc.