Identification of chiral selectors from a 200-member parallel combinatorial library.
Identification of chiral selectors from a 200-member parallel combinatorial library.
复制标题
从 200 个成员的并行组合库中识别手性选择器。
DOI：
10.1021/ac000529e
复制
发表时间：
2000
影响因子：
7.4
通讯作者：
T. Li
中科院分区：
文献类型：
--
作者：
Y. Wang;L. Bluhm;T. Li
利用在聚合合成树脂上制备的200元平行文库研究了拆分外消旋N-（1-萘基）亮氨酸酯1的手性选择剂的选择。通过本研究，改进了先前制定的图书馆筛选程序，并解决了筛选过程中的其他相关问题。筛选所需的平衡时间从24小时减少到约3小时。树脂间歇平衡实验与色谱分离之间的结果具有良好的相关性。结果表明，该筛选方法可筛选出分离因子低至1.4的筛选物。此外，该平行文库研究还获得了大量关于对映选择相互作用的信息。这些信息将有助于改进未来的图书馆设计。
Selection of chiral selectors for the resolution of racemic N-(1-naphthyl)leucine ester 1 was studied with a 200-member parallel library prepared on polymeric synthesis resin. Through this study, the library screening procedure developed previously is improved and other pertinent issues concerning the screening process are also addressed. The equilibration time required for screening is reduced from 24 h to approximately 3 h. Excellent correlation of the outcome between the resin batch equilibration experiment and chromatographic separation is further demonstrated. It is also demonstrated that selectors with separation factors as low as 1.4 could be identified by this batch screening process. In addition, a great deal of information regarding enantioselective interactions was obtained in this parallel library study. Such information should prove useful in improving future library designs.