PROBABLE ALZHEIMER-DISEASE - DIAGNOSIS WITH PROTON MR SPECTROSCOPY
PROBABLE ALZHEIMER-DISEASE - DIAGNOSIS WITH PROTON MR SPECTROSCOPY
复制标题
DOI：
10.1148/radiology.195.1.7892497
复制
发表时间：
1995-04-01
期刊：
影响因子：
19.7
通讯作者：
ROSS, BD
中科院分区：
文献类型：
--
作者：
SHONK, TK;MOATS, RA;ROSS, BD
目得：为了区分可能的阿尔茨海默病（AD）与其他痴呆（ODs）和正常老年人。材料和方法：对114例痴呆患者的枕叶皮质进行了质子磁共振波谱分析的双盲试验，主要研究灰质结果：AD患者脑组织中N-乙酰天冬氨酸（NAA）水平降低（P
PURPOSE: To distinguish probable Alzheimer disease (AD) from other dementias (ODs) and normality in the elderly.MATERIALS AND METHODS: A double-blind trial of proton magnetic resonance (MR) spectroscopy was performed, principally in gray matter, in the occipital cortex of 114 patients with dementia (AD [n = 65], OD [n = 39], or frontal lobe dementia [FLD] [n = 10]), 98 patients without dementia, and 32 healthy control subjects.RESULTS: Reduced levels of N-acetylaspartate (NAA) (P