Biotransformation of sophoricoside in Fructus sophorae by the fungus Schizophyllum commune
Biotransformation of sophoricoside in Fructus sophorae by the fungus Schizophyllum commune
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裂褶菌生物转化槐糖苷
DOI：
10.1016/j.biortech.2012.02.038
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发表时间：
2012-05-01
影响因子：
11.4
通讯作者：
Zhang, Xiaoyu
中科院分区：
文献类型：
--
作者：
Wu, Jianguo;Yang, Xialu;Zhang, Xiaoyu
利用裂褶菌对苦参中的苦参皂苷进行了生物转化。核磁共振和MS分析表明，苦参皂苷首先被代谢成4‘，5，7-三羟基异黄酮(2)，然后再代谢成4’，7-二羟基-5-甲氧基异黄酮(3)和5，7-二羟基-4‘-甲氧基异黄酮(4)。化合物(2)的含量增加了30倍以上，化合物(3)是一种具有良好的细胞毒活性的新产品，其对MCF-7细胞的IC50为12.1nmol/ml。(C)2012爱思唯尔有限公司。保留所有权利。
Biotransformation of sophoricoside in Fructus sophorae was performed with Schizophyllum commune. Sophoricoside was firstly metabolized to 4',5,7-trihydroxyisoflavone (2), and then to 4',7-dihydroxy-5-methoxyisoflavone (3) and 5,7-dihydroxy-4'-methoxyisoflavone (4) as determined by NMR and MS analyzes. The content of compound (2) was increased by more than 30-fold, and compound (3) is a new product that showed good cytotoxic activity with an IC50 of 12.1 nmol/ml against MCF-7 cells. (C) 2012 Elsevier Ltd. All rights reserved.