Ecotoxicological effects, water quality standards and risk assessment for the anti-diabetic metformin
Ecotoxicological effects, water quality standards and risk assessment for the anti-diabetic metformin
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DOI：
10.1016/j.envpol.2018.09.031
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发表时间：
2018-12-01
影响因子：
8.9
通讯作者：
Kummrow, Fabio
中科院分区：
文献类型：
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作者：
Godoy, Aline Andrade;Domingues, Ines;Kummrow, Fabio
二甲双胍(MET)是世界上消费最多的药物之一。这种化合物经常在淡水地表水中被检测到。然而，MET的生态毒理学信息仍然太有限，特别是关于慢性和行为数据。这项研究旨在帮助填补这些知识空白，通过对来自三个不同营养水平的四个不同测试生物体进行急性和慢性研究。我们评估了不同的终点，包括Danio rerio幼虫的游泳行为。我们还得出了保护淡水中上层生物群免受MET不利影响的短期和长期环境质量标准(EQS)。考虑到最坏的情况，计算了淡水中MET的风险商(RQ)。到目前为止，相似水蚤是最敏感的物种。经相似盾叶蝉繁殖试验，获得了4.4mgEC10值的L-1。求出了88亩L-1的长期等效商，RQ为0.38。考虑到终点和标准方案中通常建议的标准生物测定，预计中上层淡水物种长期暴露于多氯甲烷不会造成生态风险。然而，不能排除MET与其他共生污染物的内分泌干扰效应和潜在的相互作用效应。据我们所知，这项研究首次提供了与多效唑对相似水母和水母种群终点的影响以及对水母运动活动的影响的数据。(C)2018爱思唯尔有限公司。保留所有权利。
Metformin (MET) is among the most consumed pharmaceuticals worldwide. This compound has been frequently detected in fresh surface water. However, ecotoxicological information for MET is still too limited, particularly regarding chronic and behavioral data. This study aimed to help filling these knowledge gaps, by carrying out both acute and chronic studies with four different test organisms from three different trophic levels. We assessed different endpoints, including the swimming behavior of Danio rerio larvae. We also derived both short-term and long-term environmental quality standards (EQS) for the protection of freshwater pelagic biota towards MET adverse effects. A risk quotient (RQ) was calculated for MET in fresh surface water, considering a worst-case scenario. Daphnia similis was by far the most sensitive species evaluated. An EC10 of 4.4 mg L-1 was obtained from the reproduction test with D. similis. A long-term EQS of 88 mu g L-1 was derived and a RQ of 0.38 was obtained. An ecological risk is not expected for the chronic exposure of pelagic freshwater species to MET, considering the endpoints and the standard bioassays usually recommended in standard protocols. However, endocrine disruptive effects and potential interactive effects of MET with other co-occurring contaminants cannot be ruled out. To the best of our knowledge, this study presents the first data related with MET effects on population endpoints of D. similis and Hydra attenuata, as well as on the locomotor activity of D. rerio. (C) 2018 Elsevier Ltd. All rights reserved.