Rates of ethanol metabolism decrease in sons of alcoholics following a priming dose of ethanol.
Rates of ethanol metabolism decrease in sons of alcoholics following a priming dose of ethanol.
复制标题
酗酒者的儿子在摄入初始剂量的乙醇后，乙醇代谢率会降低。
DOI：
10.1016/j.alcohol.2007.04.002
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发表时间：
2007
期刊：
影响因子：
--
通讯作者：
Garbutt,JamesC
中科院分区：
文献类型：
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作者：
Bradford,BlairU;Karnitsching,Jennifer;Powell,LindaL;Garbutt,JamesC
在动物和人类中观察到，急性乙醇施用导致乙醇代谢率发生快速变化。为了检查这种现象是否会因酗酒风险而异，我们将 23 名有酗酒家族史（家族史阳性 [FHP]）的年轻男性与 15 名没有酗酒家族史（家族史阴性 [FHN]）的年轻男性进行了比较。首先在初始乙醇剂量（0.85g/kg）后测量所有受试者的乙醇代谢率，然后在几个小时后测量第二次剂量（0.3g/kg），并对两个比率进行比较。两组受试者的乙醇消费史相似。 FHP 受试者表现出更快的乙醇代谢初始速率（148±36mg/kg/h），而 FHN 受试者则为 124±18mg/kg/h（124±18mg/kg/h），P=.01。然而，FHN 受试者的新陈代谢率增加了 10±27%，而 FHP 受试者的新陈代谢率下降了 -15±24%，P=.007。 52% 的 FHP 受试者和没有任何 FHN 受试者表现出代谢率下降 20% 或更多，P=.0008。由于很大一部分 FHP 受试者表现出乙醇二次代谢率下降，这些初步数据可能有助于部分解释为什么 FHP 个体对乙醇的敏感性不同，并且更有可能发展成酒精依赖。
Rapid changes in rates of ethanol metabolism in response to acute ethanol administration have been observed in animals and humans. To examine whether this phenomenon might vary by risk for alcoholism, 23 young men with a positive family history of alcoholism (family history positive [FHP]) were compared to 15 young men without a family history of alcoholism (family history negative [FHN]). Rates of ethanol metabolism were measured in all subjects first after an initial ethanol dose (0.85g/kg) and then, several hours later, a second dose (0.3g/kg), and the two rates were compared. The two groups of subjects were similar in their histories of ethanol consumption. FHP subjects demonstrated faster initial rates of ethanol metabolism, 148±36mg/kg/h, compared to FHN subjects, 124±18mg/kg/h, P=.01. However, FHN subjects increased their rate of metabolism by 10±27% compared to a decrease of −15±24% in FHP subjects, P=.007. Fifty-two percent of the FHP and none of the FHN subjects exhibited a decline in metabolic rate of 20% or more, P=.0008. Since a significant proportion of FHP subjects exhibited a decrease in the second rate of ethanol metabolism, these preliminary data might help to partly explain why FHP individuals differ in their sensitivity to ethanol and are more likely to develop alcohol dependence.