MEASUREMENT OF RENAL FUNCTION WITHOUT URINE COLLECTION - CRITICAL EVALUATION OF CONSTANT INFUSTION TECHNIQUE FOR DETERMINATION OF INULIN AND PARA-AMINOHIPPURATE
MEASUREMENT OF RENAL FUNCTION WITHOUT URINE COLLECTION - CRITICAL EVALUATION OF CONSTANT INFUSTION TECHNIQUE FOR DETERMINATION OF INULIN AND PARA-AMINOHIPPURATE
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DOI：
10.1056/nejm197211302872202
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发表时间：
1972-01-01
影响因子：
158.5
通讯作者：
INGELFINGER, JR
中科院分区：
文献类型：
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作者：
COLE, BR;GIANGIACOMO, J;INGELFINGER, JR
婴儿和儿童肾功能的评估是困难的问题，在获得完整的尿液收集。在61例患者中比较了传统和恒定输注法测定菊粉和对氨基马尿酸清除率，其中32例患有各种肾脏疾病。肾小球滤过率范围为1.6 - 133 ml/min。在所有肾功能水平和是否存在水肿的情况下，两种方法的菊粉清除率值密切相关（r = 0.993）。通过恒定输注技术测定的菊粉清除率平均为真实清除率的103.2%，测量对氨基马尿酸清除率的两种方法之间的相关性为r = 0.971，但输注法测定的数值平均比“真实”清除率高21.8%，据推测，这是由于肾外排泄的帕拉-通过恒定菊糖输注技术估计肾小球滤过率构成了一种简单、准确和可重复的方法，当准确的尿液收集困难时，该方法应被证明是有用的。
The assessment of renal function in infants and children is made difficult by problems in obtaining complete urine collections. The traditional and the constant-infusion methods of determining inulin and paraaminohippurate clearance were compared in 61 patients, 32 of whom had a variety of renal diseases. Glomerular filtration rates ranged from 1.6 to 133 ml per minute. Values for inulin clearance by the two methods correlated closely (r equal to 0.993) at all levels of renal function and in the presence or absence of edema. Inulin clearance by the constant-infusion technic averaged 103.2 per cent of true clearance.Correlation between the two methods of measuring para-aminohippurate clearance was r equal to 0.971, but values by the infusion method averaged 21.8 per cent above "true" clearance, presumably owing to extrarenal excretion of para-aminohippurate.The estimation of glomerular filtration rate by the technic of constant inulin infusion constitutes a simple, accurate and reproducible method that should prove to be useful when accurate urine collection is difficult.