Serotonin neuron development: shaping molecular and structural identities.
Serotonin neuron development: shaping molecular and structural identities.
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DOI：
10.1002/wdev.301
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发表时间：
2018-01
期刊：
影响因子：
--
通讯作者：
Gaspar P
中科院分区：
文献类型：
--
作者：
Deneris E;Gaspar P
5-羟色胺(5-HT)作为神经系统化学信使的持续魅力始于1953年在哺乳动物大脑中发现的5-羟色胺。这种兴趣持续了几十年的原因很多，其中一个原因是，制造5-羟色胺的少量神经元影响了大脑和脊髓几乎每个区域神经回路的兴奋性。另一个原因是，5-羟色胺功能障碍与一系列精神和神经疾病有关，其中许多与神经发育有关。这引起了人们对了解5-羟色胺神经元发育的浓厚兴趣，目的是确定它们的早期代改变是否会导致脑部疾病的易感性。在这里，我们概述了脊椎动物5-羟色胺神经元的神经解剖学组织，它们的神经发生，以及巨大的轴突结构，这使得5-羟色胺神经调节在中枢神经系统中得以扩展。我们回顾了最近的发现，揭示了5-羟色胺神经元亚型巨大多样性的分子基础，环境因素对5-羟色胺神经元发育的影响，以及5-羟色胺轴突是如何通过不同的信号通路在地形上组织的。我们综述了控制5-羟色胺神经元分化、成熟和维持的基因调控网络的研究。这些研究表明，控制5-羟色胺类递质获得的调控因素在5-羟色胺神经元的功能成熟和维持中继续发挥关键作用。对持续表达的5-羟色胺调节因子如何在生命的不同阶段控制5-羟色胺神经元以及调节网络本身如何维持提出了新的见解。
The continuing fascination with serotonin (5-HT) as a nervous system chemical messenger began with its discovery in the brains of mammals in 1953. Among the many reasons for this decades-long interest is that the small numbers of neurons that make 5-HT influence the excitability of neural circuits in nearly every region of the brain and spinal cord. A further reason is that 5-HT dysfunction has been linked to a range of psychiatric and neurological disorders many of which have a neurodevelopmental component. This has led to intense interest in understanding 5-HT neuron development with the aim of determining whether early alterations in their generation lead to brain disease susceptibility. Here, we present an overview of the neuroanatomical organization of vertebrate 5-HT neurons, their neurogenesis, and prodigious axonal architectures, which enables the expansive reach of 5-HT neuromodulation in the CNS. We review recent findings that have revealed the molecular basis for the tremendous diversity of 5-HT neuron subtypes, the impact of environmental factors on 5-HT neuron development, and how 5-HT axons are topographically organized through disparate signaling pathways. We summarize studies of the gene regulatory networks that control the differentiation, maturation and maintenance of 5-HT neurons. These studies show that the regulatory factors controlling acquisition of 5-HT-type transmitter identity continue to play critical roles in the functional maturation and the maintenance of 5-HT neurons. New insights are presented into how continuously expressed 5-HT regulatory factors control 5-HT neurons at different stages of life and how the regulatory networks themselves are maintained.
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影响因子：
2.5
作者：
AITKEN, AR;TORK, I
通讯作者：
TORK, I
DOI：
10.1073/pnas.0810793106
发表时间：
2009-06-23
影响因子：
11.1
作者：
Alenina, Natalia;Kikic, Dana;Bader, Michael
通讯作者：
Bader, Michael
影响因子：
4.6
作者：
Craven, SE;Lim, KC;Rosenthal, A
通讯作者：
Rosenthal, A
影响因子：
17.1
作者：
Decressac, Mickael;Kadkhodaei, Banafsheh;Bjorklund, Anders
通讯作者：
Bjorklund, Anders
影响因子：
16.2
作者：
Demarque, Michael;Spitzer, Nicholas C.
通讯作者：
Spitzer, Nicholas C.