Additions to Racemates: A Strategy for Developing Asymmetric Cross-Coupling Reactions
Additions to Racemates: A Strategy for Developing Asymmetric Cross-Coupling Reactions
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DOI：
10.1055/s-0040-1706033
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发表时间：
2021-04-12
期刊：
影响因子：
2
通讯作者：
Fletcher, Stephen P.
中科院分区：
文献类型：
--
作者：
Goetzke, F. Wieland;Fletcher, Stephen P.
介绍了近年来在催化不对称C（sp（3））-C（sp（3））和C（sp（3））-C（sp（2））交叉偶联反应方面的研究进展。尽管大多数催化对映选择性转化依赖于前手性或内消旋起始材料，但使用外消旋起始材料的策略很少。这些反应的关键特征是去消旋化的有效机制。本文介绍了铜催化的烷基化反应和铑催化的Suzuki-Miyauratype芳基化反应，它们的反应机理，以及它们在复杂分子合成中的应用。
In this Account, the authors describe their progress in developing catalytic asymmetric C(sp(3))-C(sp(3)) and C(sp(3))-C(sp(2)) cross-coupling reactions. Whereas most catalytic enantioselective transformations rely on prochiral or meso starting materials, strategies that use racemic starting materials are rare. Key features of these reactions are efficient mechanisms for deracemization. Here, the authors present copper-catalyzed alkylation and rhodium-catalyzed Suzuki-Miyauratype arylation reactions, their underlying mechanisms, and their applications in complex-molecule syntheses.