Localisation of Chido and Rodgers determinants to the C4d fragment of human C4
Localisation of Chido and Rodgers determinants to the C4d fragment of human C4
复制标题
Chido 和 Rodgers 决定簇对人类 C4 的 C4d 片段的定位
DOI：
10.1038/276713a0
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发表时间：
1978
期刊：
影响因子：
64.8
通讯作者：
M. Crookston
中科院分区：
文献类型：
--
作者：
C. Tilley;D. G. Romans;M. Crookston
CHIDO（Ch）和RODGERS（Rg）是存在于血浆和红细胞上的血型抗原。当Ch（参考文献1）和Rg（参考文献2）被发现是主要组织相容性复合体HLA的遗传标记时，以及当Rg阴性表型和HLA-A1，B8纯合性之间存在强烈的连锁不平衡时，对这些抗原的兴趣被激发3。当奥尼尔等人4表明血浆的Ch和Rg表型与人补体第四组分C4的电泳多态性相关，并且纯化至同质的C4抑制抗Ch和抗Rg时，Ch和Rg最近吸引了广泛的受众。我们研究了在C4转移的条件下Ch和Rg从血浆到红细胞的转移。我们在这里报告的Ch，Rg多态性和功能C4之间的相关性，并显示Ch和Rg驻留在C4d片段的分子。我们还报道了猴抗人C4d的抗血清（参考文献5）主要是抗Ch和抗Rg。
CHIDO (Ch) AND RODGERS (Rg) are blood-group antigens present in plasma and on red cells. Interest in these antigens was stimulated when Ch (ref. 1) and Rg (ref. 2) were found to be genetic markers for the major histocompatibility complex, HLA, and when strong linkage disequilibrium between the Rg-negative phenotype and HLA-A1, B8 homozygosity was noted3. Ch and Rg recently attracted a broad audience when O'Neill et al.4 showed that the Ch and Rg phenotype of plasma was correlated with the electrophoretic polymorphism of human C4, the fourth component of complement, and that C4 purified to homogeneity inhibited anti-Ch and anti-Rg. We have studied the transfer of Ch and Rg from plasma to red cells in conditions in which C4 is transferred. We report here a correlation between the Ch, Rg polymorphism and functional C4, and show that Ch and Rg reside on the C4d fragment of the molecule. We also report that a monkey antiserum to human C4d (ref. 5) is predominantly anti-Ch and anti-Rg.