Kinetics of thallium-201 in reperfused canine myocardium after coronary artery occlusion.
Kinetics of thallium-201 in reperfused canine myocardium after coronary artery occlusion.
复制标题
冠状动脉闭塞后再灌注犬心肌中 201 铊的动力学。
DOI：
10.1016/s0735-1097(84)80183-7
复制
发表时间：
1984
影响因子：
24
通讯作者：
Okada,RD
中科院分区：
文献类型：
--
作者：
Okada,RD
为了研究铊201在未挽救的急性梗塞心肌和挽救的心肌中的动力学，在闭塞后2小时实验性左前降支再灌注后施用示踪剂。然后，使用微型碲化镉辐射探测器对 19 只狗的再灌注前壁和正常后壁中的铊活性进行了 4 小时的监测。处死后，通过三苯基四唑氯化物染色发现其中13只狗前壁梗塞。在这些狗中，梗死区的平均（±标准差）分数 4 小时铊清除率为 0.33 ± 0.08，正常对照区为 0.15 ± 0.06（p < 0.001）。当进行计算机建模时，梗死区的清除曲线是双指数的。梗死区的第二条指数清除曲线在示踪剂施用后 19.1 ± 3.2 分钟开始，与正常对照区的单指数清除曲线无法区分。血池中的铊清除率为三指数，最终的指数清除曲线与正常对照区清除曲线无法区分。通过三苯基四唑氯化物染色发现六只狗具有挽救性的非梗塞前壁。在这些狗中，再灌注区的平均 4 小时铊清除率为 0.20 ± 0.07，正常对照区为 0.19 ± 0.08 (p = NS)。当计算机建模时，再灌注区和对照区的清除曲线是单指数的。挽救的再灌注区的单指数清除率曲线与正常心肌的单指数清除率曲线没有区别。因此，冠状动脉再灌注后，与挽救的非梗塞心肌相比，铊从非挽救的急性梗塞心肌中清除得更快。在快速的早期铊清除阶段之后，随后来自非挽救心肌的指数清除率与来自挽救心肌、正常心肌和血池的清除率平行。
To study the kinetics of thallium-201 in nonsalvaged acutely infarcted myocardium and salvaged myocardium, the tracer was administered after experimental left anterior descending coronary artery reperfusion 2 hours after occlusion. In 19 dogs, thallium activity was then monitored for 4 hours in the reperfused anterior wall and normal posterior wall using miniature cadmium telluride radiation detectors. After sacrifice, 13 of the dogs were found to have an infarcted anterior wall by triphenyltetrazolium-chloride staining. In these dogs, mean (± standard deviation) fractional 4 hour thallium clearance was 0.33 ± 0.08 for the infarct zone and 0.15 ± 0.06 for the normal control zone (p < 0.001). When computer-modeled, the clearance curve from the infarct zone was biexponential. The second exponential clearance curve from the infarct zone began 19.1 ± 3.2 minutes after tracer administration, and was indistinguishable from the monoexponential clearance curve from the normal control zone. Thallium clearance from the blood pool was triexponential, the final exponential clearance curve being indistinguishable from the normal control zone clearance curve.Six dogs were found to have a salvaged noninfarcted anterior wall by triphenyltetrazolium-chloride staining. In these dogs, mean fractional 4 hour thallium clearance was 0.20 ± 0.07 for the reperfused zone, and 0.19 ± 0.08 for the normal control zone (p = NS). When computer-modeled, clearance curves for the reperfused and control zones were monoexponential. The monoexponential clearance curve for the salvaged reperfused zone was indistinguishable from the monoexponential clearance curve for norma) myocardium.Thus, after coronary artery reperfusion, thallium clears faster from nonsalvaged acutely infarcted myocardium compared with salvaged noninfarcted myocardium. After a rapid early thallium clearance phase, the subsequent exponential clearance from nonsalvaged myocardium parallels the clearance from salvaged myocardium, normal myocardium and the blood pool.