Forensic genetic analysis of bio-geographical ancestry
Forensic genetic analysis of bio-geographical ancestry
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DOI：
10.1016/j.fsigen.2015.05.012
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发表时间：
2015-09-01
影响因子：
3.1
通讯作者：
Phillips, Chris
中科院分区：
文献类型：
--
作者：
Phillips, Chris
随着过去十年来在理解人类种群变异和基因组详细特征方面取得的巨大进步，现在有可能识别出一组适合于相对小规模的基于PCR的分析的祖先信息标记，并使用它们从法医DNA中分析个人的祖先。这篇综述概述了对过去人类人口结构的一些当前理解，以及它可能如何影响当代人类多样性的复杂分布。对人类多样性的简化描述可以为选择最好的血统信息标记提供适当的基础，这一点在法医DNA测试中考虑到多重大小的限制是重要的。还必须确定切合实际的地理分辨率水平，以确保在信息性和复杂人类多样性模式的过度简单化之间取得平衡。对适用于法医使用的信息最丰富的血统标记进行了详细比较，并对可提供DNA捐赠者生物地理血统统计推断的数据分析制度进行了评估。(C)2015爱思唯尔爱尔兰有限公司。保留所有权利。
With the great strides made in the last ten years in the understanding of human population variation and the detailed characterization of the genome, it is now possible to identify sets of ancestry informative markers suitable for relatively small-scale PCR-based assays and use them to analyze the ancestry of an individual from forensic DNA. This review outlines some of the current understanding of past human population structure and how it may have influenced the complex distribution of contemporary human diversity. A simplified description of human diversity can provide a suitable basis for choosing the best ancestry-informative markers, which is important given the constraints of multiplex sizes in forensic DNA tests. It is also important to decide the level of geographic resolution that is realistic to ensure the balance between informativeness and an over-simplification of complex human diversity patterns. A detailed comparison is made of the most informative ancestry markers suitable for forensic use and assessments are made of the data analysis regimes that can provide statistical inferences of a DNA donor's bio-geographical ancestry. (C) 2015 Elsevier Ireland Ltd. All rights reserved.