Breastfeeding and hospitalization for diarrheal and respiratory infection in the United Kingdom Millennium Cohort Study
Breastfeeding and hospitalization for diarrheal and respiratory infection in the United Kingdom Millennium Cohort Study
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DOI：
10.1542/peds.2006-2256
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发表时间：
2007-04-01
期刊：
影响因子：
8
通讯作者：
Sacker, Amanda
中科院分区：
文献类型：
--
作者：
Quigley, Maria A.;Kelly, Yvonne J.;Sacker, Amanda
目标。本研究的目的是衡量母乳喂养对当代英国出生后前8个月腹泻和下呼吸道感染住院治疗的影响。该研究是一项基于人群的调查（英国千年队列研究的扫1）。对2000-2002年出生的15890名健康的单胎足月婴儿提供了关于婴儿喂养、婴儿健康和一系列混杂因素的数据。主要观察指标为出生后前8个月因腹泻和下呼吸道感染住院的父母报告。70%的婴儿接受母乳喂养（曾经），34%的婴儿接受母乳喂养至少4个月，1.2%的婴儿接受纯母乳喂养至少6个月。到8个月大时，12%的婴儿住院（1.1%因腹泻，3.2%因下呼吸道感染）。按月龄对数据进行分析，并对混杂因素进行调整，结果表明，与不母乳喂养相比，纯母乳喂养可防止因腹泻和下呼吸道感染住院。部分母乳喂养的效果较弱。人口归因部分表明，估计每月53%的腹泻住院可通过纯母乳喂养预防，31%可通过部分母乳喂养预防。同样，每月27%的下呼吸道感染住院病例可以通过纯母乳喂养预防，25%可以通过部分母乳喂养预防。母乳喂养对这些结果的保护作用在停止母乳喂养后很快消失。在当代英国，母乳喂养，特别是纯母乳喂养和长时间母乳喂养，可以防止严重的发病率。在人口水平上增加纯母乳喂养和延长母乳喂养，将对公共卫生产生相当大的潜在益处。
OBJECTIVE. The objective of this study was to measure the effect of breastfeeding on hospitalization for diarrheal and lower respiratory tract infections in the first 8 months after birth in contemporary United Kingdom.METHODS. The study was a population-based survey ( sweep 1 of the United Kingdom Millennium Cohort Study). Data on infant feeding, infant health, and a range of confounding factors were available for 15 890 healthy, singleton, term infants who were born in 2000-2002. The main outcome measures were parental report of hospitalization for diarrhea and lower respiratory tract infection in the first 8 months after birth.RESULTS. Seventy percent of infants were breastfed ( ever), 34% received breast milk for at least 4 months, and 1.2% were exclusively breastfed for at least 6 months. By 8 months of age, 12% of infants had been hospitalized (1.1% for diarrhea and 3.2% for lower respiratory tract infection). Data analyzed by month of age, with adjustment for confounders, show that exclusive breastfeeding, compared with not breastfeeding, protects against hospitalization for diarrhea and lower respiratory tract infection. The effect of partial breastfeeding is weaker. Population-attributable fractions suggest that an estimated 53% of diarrhea hospitalizations could have been prevented each month by exclusive breastfeeding and 31% by partial breastfeeding. Similarly, 27% of lower respiratory tract infection hospitalizations could have been prevented each month by exclusive breastfeeding and 25% by partial breastfeeding. The protective effect of breastfeeding for these outcomes wears off soon after breastfeeding cessation.CONCLUSIONS. Breastfeeding, particularly when exclusive and prolonged, protects against severe morbidity in contemporary United Kingdom. A population-level increase in exclusive, prolonged breastfeeding would be of considerable potential benefit for public health.