Reinforcing effects of caffeine, ephedrine, and their binary combination in rats
Reinforcing effects of caffeine, ephedrine, and their binary combination in rats
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DOI：
10.1016/s0091-3057(98)00041-0
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发表时间：
1998-07-01
影响因子：
3.6
通讯作者：
Gauvin, DV
中科院分区：
文献类型：
--
作者：
Briscoe, RJ;Vanecek, SA;Gauvin, DV
在大鼠中测试咖啡因、麻黄碱和咖啡因+麻黄碱组合的强化作用，大鼠在每天4小时的有限接触期内自我给予0.5 mg/kg/注射可卡因。可卡因的量效关系呈典型的倒U型函数。可卡因的剂量依赖性给药在3天替代期内保持稳定。与先前的报告类似，咖啡因和麻黄碱都没有产生稳定的自我注射模式。咖啡因+麻黄碱的组合仅在替代的第一天产生双相给药模式。咖啡因-麻黄碱替代期的第2天和第3天产生了变量和不一致的药物递送，与盐水替代试验没有显著差异。这些自我管理的咖啡因-麻黄碱组合模式减少并不归因于行为毒性。进行比测试表明，顺序排列的断点：食物>可卡因>咖啡因-麻黄碱组合=咖啡因=麻黄碱=生理盐水。咖啡因-麻黄碱预处理未能显示可卡因维持剂量给药的任何显着变化，但在最高组合剂量测试。尽管该实验室先前的数据表明咖啡因-麻黄碱组合和可卡因的区分作用之间存在对称的交叉概括（5，6），但目前的数据表明这些组合在大鼠中的强化作用有限。(C)1998年爱思唯尔科学公司
The reinforcing effects of caffeine, ephedrine, and caffeine + ephedrine combinations were tested in rats maintained to self-administer 0.5 mg/kg/injection of cocaine in daily 4 h limited access periods. The dose-response relationship for cocaine demonstrated a a typical inverted U-shaped function. The dose-dependent administration of cocaine was stable over the 3-day substitution epochs. Similar to earlier reports, neither caffeine nor ephedrine engendered stable patterns of self-injections. Combinations of caffeine + ephedrine produced biphasic patterns of administration only on the first day of substitution. Days 2 and 3 of the caffeine-ephedrine substitution periods engendered variable and inconsistent reinforcer deliveries that did not significantly differ from saline substitution tests. These reduced patterns of self-administered caffeine-ephedrine combinations were not attributed to behavioral toxicity. Progressive-ratio tests demonstrated rank ordered break points of: food > cocaine > caffeine-ephedrine combination = caffeine = ephedrine = saline. Caffeine-ephedrine pretreatments failed to show any significant change in the administration of the maintenance dose of cocaine except at the highest combination dose tested. Although previous data from this laboratory demonstrated symmetrical crossgeneralization between the discriminative effects of caffeine-ephedrine combinations and cocaine (5,6), the present data suggest limited reinforcing effects of these combinations in rats. (C) 1998 Elsevier Science Inc.