Contrasting effects of different levels of food intake and adiposity on LH secretion and hypothalamic gene expression in sheep
Contrasting effects of different levels of food intake and adiposity on LH secretion and hypothalamic gene expression in sheep
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DOI：
10.1677/joe.0.1750383
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发表时间：
2002-11-01
影响因子：
4
通讯作者：
Adam, CL
中科院分区：
文献类型：
--
作者：
Archer, ZA;Rhind, SM;Adam, CL
身体储备（长期）和食物摄入（短期）都有助于下丘脑的营养反馈。生殖神经内分泌输出（GnRH/LH）刺激增加食物摄入量，而不是由高肥胖的绵羊，但它是未知的食欲调节下丘脑神经元是否显示这种差异的反应。在两个为期4周的实验中研究了雌二醇植入的去势雄性绵羊（苏格兰黑脸）。在实验1中，饲喂绵羊以维持初始身体状况（BC）评分为2.0 +/- 0.00（较低BC（LBC），n=7）或2.9 +/- 0.09（较高BC（HBC），n=9），活重分别为43 +/- 1.1和59 +/- 1.6 kg。LBC和HBC绵羊的平均血浆LH浓度、脉冲频率和幅度相似，但HBC动物的平均血浆胰岛素浓度较高（P
Body reserves (long-term) and food intake (short-terns) both contribute nutritional feedback to the hypothalamus. Reproductive neuroendocrine output (GnRH/LH) is stimulated by increased food intake and not by high adiposity in sheep, but it is unknown whether appetite-regulating hypothalamic neurons show this differential response. Castrated male sheep (Scottish Blackface) with oestradiol implants were studied in two 4 week experiments. In Experiment 1, sheep were fed to maintain the initial body condition (BC) score of 2.0 +/- 0.00 (lower BC (LBC), n=7) or 2.9 +/- 0.09 (higher BC (HBC), n=9), and liveweight of 43 +/- 1.1 and 59 +/- 1.6 kg respectively. LBC and HBC sheep had similar mean plasma LH concentration, pulse frequency and amplitude, but HBC animals had higher mean plasma concentrations of insulin (P