Burnout, perceived stress, and cortisol responses to awakening
Burnout, perceived stress, and cortisol responses to awakening
复制标题
DOI：
10.1097/00006842-199903000-00012
复制
发表时间：
1999-03-01
影响因子：
3.3
通讯作者：
Kirschbaum, C
中科院分区：
文献类型：
--
作者：
Pruessner, JC;Hellhammer, DH;Kirschbaum, C
目的：探讨职业倦怠和知觉压力对教师清晨清醒后游离皮质醇水平的影响。先前的研究表明，皮质醇水平在觉醒后显着增加，具有较高的个体内稳定性。研究方法：来自当地公立学校的66名教师（42名女性和24名男性，平均年龄42 ± 5岁）被要求连续3天采集唾液进行皮质醇分析。每天，在觉醒时以及之后的15、30和60分钟测量皮质醇水平。第3天前一晚，受试者口服0.5 mg地塞米松，用于糖皮质激素反馈抑制试验。倦怠和感知压力测量三个不同的问卷。结果：地塞米松预处理后觉醒后第一个小时内，知觉压力与皮质醇水平的增加相关。此外，教师得分高的倦怠表现出较低的整体皮质醇分泌的所有采样日，和更高的抑制皮质醇分泌后地塞米松管理。在高水平的知觉压力和高水平的倦怠教师的亚组，较低的整体皮质醇分泌观察到的前2天，与地塞米松抑制后醒来后的第一个小时内更强的增加。这个小组也表现出最低的自尊，最高的外部控制点，和最高数量的躯体投诉。结论：这些结果表明倦怠和知觉压力对下丘脑-垂体-肾上腺轴调节的不同影响。
Objective: The effects of burnout and perceived stress on early morning free cortisol levels after awakening were investigated in a group of teachers. Previous studies revealed that cortisol levels show a significant increase after awakening, with high intraindividual stability. Methods: Sixty-six teachers from local public schools (42 women and 24 men, mean age 42 +/- 5 years) were asked to sample saliva for cortisol analysis on 3 consecutive days. On each day, cortisol levels were measured at the time of awakening and 15, 30, and 60 minutes thereafter. On the night before the third day, subjects took 0.5 mg dexamethasone orally for testing glucocorticoid feedback inhibition. Burnout and perceived stress were measured by three different questionnaires. Results: Perceived stress correlated with increases of cortisol levels during the first hour after awakening after dexamethasone pretreatment. In addition, teachers scoring high on burnout showed lower overall cortisol secretion on all sampling days, and a higher suppression of cortisol secretion after dexamethasone administration. In the subgroup of teachers with both high levels of perceived stress and high levels of burnout, a lower overall cortisol secretion was observed on the first 2 days, with stronger increases during the first hour after awakening after dexamethasone suppression. This subgroup also showed the lowest self-esteem, the highest external locus of control, and the highest number of somatic complaints. Conclusions: These results demonstrate differential effects of burnout and perceived stress on hypothalamic-pituitary-adrenal axis regulation.