Isolation of an Infectious Endogenous Retrovirus in a Proportion of Live Attenuated Vaccines for Pets
Isolation of an Infectious Endogenous Retrovirus in a Proportion of Live Attenuated Vaccines for Pets
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DOI：
10.1128/jvi.02715-09
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发表时间：
2010-04-01
影响因子：
5.4
通讯作者：
Palmarini, Massimo
中科院分区：
文献类型：
--
作者：
Miyazawa, Takayuki;Yoshikawa, Rokusuke;Palmarini, Massimo
所有动物物种的基因组都被内源性逆转录病毒（ERV）定殖。尽管大多数 ERV 都积累了使其无法复制的缺陷，但已在各种哺乳动物中发现了完全感染性的 ERV。在这项研究中，我们在一定比例的宠物减毒活疫苗中分离出了猫传染性 ERV (RD-114)。 RD-114 的分离是在两个独立实验室使用不同的检测策略并使用日本或英国市售的猫和狗疫苗进行的。这项研究表明，应重新评估目前用于筛选兽用疫苗中逆转录病毒的方法。
The genomes of all animal species are colonized by endogenous retroviruses (ERVs). Although most ERVs have accumulated defects that render them incapable of replication, fully infectious ERVs have been identified in various mammals. In this study, we isolated a feline infectious ERV (RD-114) in a proportion of live attenuated vaccines for pets. Isolation of RD-114 was made in two independent laboratories using different detection strategies and using vaccines for both cats and dogs commercially available in Japan or the United Kingdom. This study shows that the methods currently employed to screen veterinary vaccines for retroviruses should be reevaluated.