Long-term Treatment With Proton Pump Inhibitors Is Effective in Children With Eosinophilic Esophagitis
Long-term Treatment With Proton Pump Inhibitors Is Effective in Children With Eosinophilic Esophagitis
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DOI：
10.1097/mpg.0000000000001952
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发表时间：
2018-08-01
影响因子：
2.9
通讯作者：
Roman, Enriqueta
中科院分区：
文献类型：
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作者：
Gutierrez-Junquera, Carolina;Fernandez-Fernandez, Sonia;Roman, Enriqueta
目的：质子泵抑制剂（PPI）反应性嗜酸性食管炎（EoE）在儿童中经常观察到，但长期治疗的数据很少。本研究的目的是评估长期的有效性和安全性PPIs在儿童EoE.Methods：这项前瞻性研究招募儿童EoE和组织学缓解的为期8周的埃索美拉唑试验（1毫克/公斤/剂，每天两次）。艾司氯胺酮以1 mg/kg/天维持1年。监测症状复发和不良事件，并在12个月时进行随访内窥镜检查。完全组织学缓解定义为5，
Objectives: Proton pump inhibitor (PPI)-responsive eosinophilic esophagitis (EoE) is frequently observed in children, but data on long-term treatment are scarce. The objective of this study is to evaluate the long-term efficacy and safety of PPIs in children with EoE.Methods: This prospective study enrolled children with EoE and histological remission to an 8-week esomeprazole trial (1 mg/kg/dose, twice daily). Esomeprazole was maintained at 1 mg/kg/day for 1 year. Symptom recurrence and adverse events were monitored and a follow-up endoscopy was performed at 12 months. Complete histological remission was defined as 5 and