Resistin induces insulin resistance in pancreatic islets to impair glucose-induced insulin release
Resistin induces insulin resistance in pancreatic islets to impair glucose-induced insulin release
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DOI：
10.1016/j.bbrc.2006.12.134
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发表时间：
2007-02-23
影响因子：
3.1
通讯作者：
Yada, Toshihiko
中科院分区：
文献类型：
--
作者：
Nakata, Masanori;Okada, Takashi;Yada, Toshihiko
An adipokine resistin, a small cysteine-rich protein, is one of the major risk factors of insulin resistance. In the present study, transiently resistin-expressing mice using adenovirus method showed an impaired glucose tolerance due to insulin resistance. We found that resistin-expressing mice exhibited impaired insulin secretory response to glucose. In addition, in vitro treatment with resistin for I day induced insulin resistance in pancreatic islets and impaired glucose-stimulated insulin secretion by elevating insulin release at basal glucose (2.8 mM) and suppressing insulin release at stimulatory glucose (8.3 mM). In addition, resistin inhibited insulin-induced phosphorylation of Akt in islets as well as other insulin target organs. Furthermore, resistin induced SOCS-3 expression in P-cells. In conclusion, resistin induces insulin resistance in islet beta-cells at least partly via induction of SOCS-3 expression and reduction of Akt phosphorylation and impairs glucose-induced insulin secretion. (c) 2006 Elsevier Inc. All rights reserved.
