Adipose tissue macrophages: the inflammatory link between obesity and cancer?
Adipose tissue macrophages: the inflammatory link between obesity and cancer?
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DOI：
10.1517/14728222.2014.991311
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发表时间：
2015-03
影响因子：
5.8
通讯作者：
M. Wagner;Eli Sihn Samdal Steinskog;H. Wiig
中科院分区：
文献类型：
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作者：
M. Wagner;Eli Sihn Samdal Steinskog;H. Wiig
在过去的三十年里，肥胖急剧增加。因此，将肥胖和癌症联系起来的流行病学证据激发了我们对脂肪组织质量和癌症发展之间关系的兴趣。肥胖被定义为脂肪组织过量，以巨噬细胞浸润引发的慢性、低度炎症反应为典型。因此，在这篇综述中，我们将讨论肥胖引起的慢性炎症与癌症之间的推定因果关系，并特别关注脂肪组织巨噬细胞。涵盖领域：慢性、低度炎症长期以来与癌症的发生、促进和进展有关。因此，来自脂肪组织巨噬细胞的信号可能在癌变过程中发挥重要作用。在这篇综述中，我们将讨论肥胖中癌症发展的分子机制，并强调针对脂肪组织巨噬细胞的可能治疗策略。专家意见：肿瘤相关巨噬细胞浸润与肿瘤生长进展之间的强相关性强调了巨噬细胞作为有效治疗靶点的价值。脂肪组织巨噬细胞在多大程度上参与了这些过程，特别是在脂肪组织内或脂肪组织附近生长的肿瘤中，仍有待破译。更多的努力也应该放在阐明人类和小鼠之间巨噬细胞的差异，这可能会导致更有效的诊断和治疗策略的发展。
Introduction: Obesity has increased dramatically over the last three decades. Thus, epidemiological evidence linking obesity and cancer has ignited our interest in the relationship between adipose tissue mass and cancer development. Obesity is defined as an excess of adipose tissue that is typified by a chronic, low-grade inflammatory response instigated by macrophage infiltration. Therefore, in this review, we will discuss the putative causal relationship between obesity-induced chronic inflammation and cancer with particular focus on adipose tissue macrophages. Areas covered: Chronic, low-grade inflammation has long been associated with cancer initiation, promotion and progression. Therefore, signals derived from adipose tissue macrophages may play a significant role in carcinogenesis. In this review we will discuss the molecular mechanisms of cancer development in obesity and highlight possible therapeutic strategies aiming at adipose tissue macrophages. Expert opinion: The strong correlation between tumor-associated macrophage infiltration and tumor growth and progression emphasizes the value of macrophages as an effective therapeutic target. It remains to be deciphered to what extent adipose tissue macrophages contribute to these processes, especially in tumors growing within or adjacent to adipose tissue. More effort should also be placed on elucidating macrophage differences between humans and mice that may lead to the development of more effective diagnostic and therapeutic strategies.